Base by Base
Gustavo BarraBase by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical relevance—one base at a time. Powered by AI, Base by Base offers a new way to learn on the go. Special thanks to authors who publish under CC BY 4.0, maki... more
| Publishes | Daily | Episodes | 405 | Founded | a year ago |
|---|---|---|---|---|---|
| Number of Listeners | Categories | Health & FitnessScienceLife SciencesMedicine | |||
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Latest Episodes
Baya N et al., The American Journal of Human Genetics 113, 1–19 (2026) - Baya et al. applied a misalignment framework to UK Biobank polygenic scores and exomes and found that individuals whose observed phenotypes deviate from polygenic expectation ar... more
Fluri R et al., The American Journal of Human Genetics - This episode examines a cohort study of 16 individuals with de novo LDB1 variants that reveals two overlapping but distinct neurodevelopmental phenotypes tied to variant location. Functional as... more
Mastrorosa F et al., The American Journal of Human Genetics - Long-read assemblies and epigenetic mapping of chromosome 21 centromeres in families with trisomy 21 reveal centromere size diversity, two cases of extreme maternal centromere size asymmet... more
Shi Z et al., The American Journal of Human Genetics - A large GWAS meta-analysis across five biobanks (8,969 cases, 1,962,542 controls) identifies five genome-wide significant loci for Ménière disease, implicating developmental regulators EYA1/EYA4 ... more
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Apple Podcasts | #196 |  Germany/Science/Life Sciences |
Apple Podcasts | #50 |  Brazil/Science/Life Sciences |
Apple Podcasts | #50 |  South Africa/Science/Life Sciences |
Apple Podcasts | #63 |  Belgium/Science/Life Sciences |
Apple Podcasts | #94 |  Singapore/Science/Life Sciences |
Apple Podcasts | #104 |  China/Science/Life Sciences |
Apple Podcasts | #134 |  Sweden/Science/Life Sciences |
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Frequently Asked Questions About Base by Base
What is Base by Base about and what kind of topics does it cover?
A deep dive into cutting-edge genetics and genomics research, with episodes covering innovative techniques for mapping gene expression in tissues, strategies to map drug resistance in cancer, and advances in RNA-targeting CRISPR systems. Discussions often center on how new open-access studies can translate to clinical practice, from multiomic spatial mapping and immunoproteasome biology to RNA-targeting diagnostics and genetic-code malleability. A notable throughline is the emphasis on practical applications—proactive cancer strategies, diagnostic innovations, and the potential for personalized medicine—coupled with a strong openness ethos driven by CC BY 4.0 licensing. Listeners can expect rigorous explanations of experimental methods, tra... more
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How many episodes of Base by Base are there?
Base by Base launched a year ago and published 405 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.
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What guests have appeared on Base by Base?
Recent guests on Base by Base include:
1. Matu Mantecon
2. Agnes Roetig
3. Jirko Kuhnisch
4. Kaneco Weaver
5. Ruby White
6. Christophe Pellefigues
7. Franca Ronchese
8. Olivier Lamiable
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