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Base by Base

Gustavo Barra
TRMT1
Preterm Birth
Structural Variation
Splice-Altering Variants
Genomics
Neurodevelopmental Disorder
MUTYH
Cell-Free DNA
Genetic Disorders
CXCL12
Cell-Free DNA (cfdna)
Trna
High-Resolution Variant Frequencies
NOMADSV
Antisense Oligonucleotides
Guidelines For Pathogenic DNA Variants
Colorectal Cancer
Genetics
BRCA1
Blood Collection

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical relevance—one base at a time. Powered by AI, Base by Base offers a new way to learn on the go. Special thanks to authors who publish under CC BY 4.0, maki... more

PublishesDailyEpisodes174Founded6 months ago
Number of ListenersCategories
MedicineHealth & FitnessLife SciencesScience

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Latest Episodes

️ Episode 174: TMEM217–SLC9C1: Wiring the cAMP Switch for Sperm Motility and Male Fertility

In this episode of PaperCast Base by Base, we explore a PNAS study revealing how TMEM217 forms a complex with the sperm-specific Na+/H+ exchanger SLC9C1 to ... more

️ Episode 173: Bottlebrush Block Copolymer Shields Muscles and Prevents DMD Onset

In this episode of PaperCast Base by Base, we explore a PNAS study showing how a synthetic bottlebrush block copolymer can act as a powerful membrane stabilizer to pr... more

️ Episode 172: When Random DNA Fights Back: De Novo Gene Birth as Antiphage Defense

In this episode of PaperCast Base by Base, we explore a PNAS study showing that short, previously nongenic DNA sequences can quickly evolve into genes that help bac... more

️ Episode 171: Virulence Hierarchies in the Tuberculosis Complex—What Makes Some Lineages Deadlier?

In this episode of PaperCast Base by Base, we explore a new PNAS study that directly compares the virulence of Mycobacterium tuberculosis, M. bovis,... more

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Recent Guests

Research Team from Duke University
Team that developed DeepScence and CoreScence.
Duke University
Episode: 167: DeepScence: Detecting Senescent Cells at Single-Cell and Spatial Resolution
Tianxin Zeng
Researcher affiliated with Stanford University
Stanford University
Episode: 149: Cultural Hitchhiking and the Post‑Neolithic Y‑Chromosome Bottleneck
Alan J. Aw
Researcher affiliated with Stanford University
Stanford University
Episode: 149: Cultural Hitchhiking and the Post‑Neolithic Y‑Chromosome Bottleneck
Marcus W. Feldman
Researcher affiliated with Stanford University
Stanford University
Episode: 149: Cultural Hitchhiking and the Post‑Neolithic Y‑Chromosome Bottleneck
Anna Axakova
A researcher actively working on SOD1 variants and ALS.
University of Toronto
Episode: 140: Landscapes of missense variant impact for human superoxide dismutase 1
Megan Ding
A researcher contributing to the understanding of SOD1 gene.
University of Pittsburgh
Episode: 140: Landscapes of missense variant impact for human superoxide dismutase 1
Jacques Fellay
Lead researcher at Ecole Polytechnique Federale de Lausanne
Ecole Polytechnique Federale de Lausanne
Episode: 139: MosCoverY: A new method to estimate mosaic loss of Y chromosome from sequencing coverage data
Dr. Lucas da Silva
Lead researcher and contributor to the study on the qPCR assay for Monkeypox.
Sabin Diagnóstico e Saúde
Episode: ️ 61: Monkeypox on the Frontline — Developing Brazil’s First qPCR Diagnostic Assay
Elena Fusari
Lead researcher of the study on aneuploid cells
Cell Genomics
Episode: ️ 58: Aneuploid Cells and Cellular Battles — How Cell Interactions Shape Genome Integrity

Host

Host 1
Host of Base by Base, involved in discussing genetic advancements and their implications.

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173: Bottlebrush Block Copolymer Shields Muscles and Prevents DMD Onset
Q: Does this synthetic polymer really prevent the disease progression?
Yes, in the study, early treatment with the polymer completely stopped the spike in muscle damage markers in the treated mice.
173: Bottlebrush Block Copolymer Shields Muscles and Prevents DMD Onset
Q: What if we could patch the damaged membranes with a synthetic molecule?
Using a synthetic polymer, muscle membranes can be stabilized effectively, demonstrating a new treatment approach for DMD.
133: Culture-Independent Meta‑Pangenomics Reveals Gut Genome Links to Child Growth
Q: What were the main findings in relation to microbial diversity and childhood growth?
Children experiencing linear growth faltering exhibited higher microbial richness but also higher genome instability, linking microbial health to growth outcomes.
133: Culture-Independent Meta‑Pangenomics Reveals Gut Genome Links to Child Growth
Q: How did the research team improve upon previous methods of studying gut microbiomes?
They utilized culture-independent metapanogenomics and long-read sequencing to recover complete microbial genomes, allowing them to analyze genetic variations more effectively and in significant detail.
133: Culture-Independent Meta‑Pangenomics Reveals Gut Genome Links to Child Growth
Q: What were researchers missing with the older techniques when studying pediatric undernutrition?
Researchers previously focused on static measurements and 16S RNA gene sequencing, which provided a broad overview but lacked crucial details necessary to understand the full genetic potential of gut microbes.

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Frequently Asked Questions About Base by Base

What is Base by Base about and what kind of topics does it cover?

Exploring the cutting edge of genetics and genomics, this podcast offers a comprehensive look at gene-disease associations, variant interpretation, and protein structure. Episodes feature in-depth discussions on significant studies related to exome and genome sequencing, emphasizing their clinical implications and practical applications. Each installment aims to simplify complex scientific concepts, providing listeners with clear insights into advancements in the field, making it particularly valuable for both professionals and enthusiasts looking to stay informed about the latest trends in genetic research. The engaging approach empowers listeners to learn at their convenience while fostering an appreciation for open-access scientific lite... more

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1. The Daily

How many episodes of Base by Base are there?

Base by Base launched 6 months ago and published 174 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on Base by Base?

Recent guests on Base by Base include:

1. Research Team from Duke University
2. Tianxin Zeng
3. Alan J. Aw
4. Marcus W. Feldman
5. Anna Axakova
6. Megan Ding
7. Jacques Fellay
8. Dr. Lucas da Silva

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