Base by Base
Gustavo BarraBase by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical relevance—one base at a time. Powered by AI, Base by Base offers a new way to learn on the go. Special thanks to authors who publish under CC BY 4.0, maki... more
| Publishes | Daily | Episodes | 369 | Founded | a year ago |
|---|---|---|---|---|---|
| Number of Listeners | Categories | Health & FitnessLife SciencesMedicineScience | |||
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Latest Episodes
Singh P et al., PNAS - This paper compares alternative splicing (AS) and gene expression (GE) across 200 transcriptomes from oral and pharyngeal jaws of 18 haplochromine cichlid species across Lakes Victoria, Malawi, and Tanganyika. The authors show ... more
Han YJ et al., Proceedings of the National Academy of Sciences (PNAS) - This episode examines a PNAS study showing that the BRCA1 pseudogene BRCA1P1 produces circular RNAs that suppress antiviral innate immunity in human cancers; depleting BRCA1P1 ac... more
Bourgeois et al., Nature Communications - This study used enhanced CRISPR base editor screens, structural biology, biochemical assays, and in vitro/in vivo selection to map MEN1 mutations that drive resistance to five clinical menin inhibitors and to... more
Kalinowski A et al., PNAS - This study reports that C4 protein is enriched in human neutrophils and monocytes and that neutrophil C4 protein levels correlate with C4A gene copy number specifically in people with schizophrenia, linking peripheral inna... more
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Apple Podcasts | #245 |  United Kingdom/Science/Life Sciences |
Apple Podcasts | #50 |  Germany/Science/Life Sciences |
Apple Podcasts | #12 |  Sweden/Science/Life Sciences |
Apple Podcasts | #29 |  Singapore/Science/Life Sciences |
Apple Podcasts | #81 |  Japan/Science/Life Sciences |
Apple Podcasts | #135 | Sweden/Science |
Apple Podcasts | #210 | Singapore/Science |
Apple Podcasts | #235 |  Netherlands/Science/Life Sciences |
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Frequently Asked Questions About Base by Base
What is Base by Base about and what kind of topics does it cover?
This show centers on advances in genetics and genomics, with a strong emphasis on how new studies translate to clinical understanding. Episodes commonly unpack topics like biobank biases, polygenic risk scores, transcriptional and regulatory mechanisms, genome-wide association methods, and the practicalities of implementing genomic insights in healthcare. Across installments, the hosts tend to connect methodological nuances to real-world implications—ranging from diagnostic yield and disease risk prediction to ethical considerations and health equity—often highlighting innovative analytic techniques (e.g., weighting schemes, NLP in clinical data, and population-specific reference resources) and the challenges of translating cutting-edge res... more
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Which podcasts are similar to Base by Base?
These podcasts share a similar audience with Base by Base:
1. Brain Talk | Being Patient for Alzheimer's Patients and Caregivers
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3. Better Brain Fitness (a Brainjo Production)
4. The Proof with Simon Hill
5. Mind Pump: Raw Fitness Truth
How many episodes of Base by Base are there?
Base by Base launched a year ago and published 369 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.
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What guests have appeared on Base by Base?
Recent guests on Base by Base include:
1. Matu Mantecon
2. Agnes Roetig
3. Jirko Kuhnisch
4. Kaneco Weaver
5. Ruby White
6. Christophe Pellefigues
7. Franca Ronchese
8. Olivier Lamiable
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