Base by Base
Gustavo BarraBase by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical relevance—one base at a time. Powered by AI, Base by Base offers a new way to learn on the go. Special thanks to authors who publish under CC BY 4.0, maki... more
| Publishes | Daily | Episodes | 352 | Founded | a year ago |
|---|---|---|---|---|---|
| Number of Listeners | Categories | MedicineScienceLife SciencesHealth & Fitness | |||
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Latest Episodes
Hou P et al., PNAS - This study combines kinetic assays and X‑ray crystallography to show how 8‑oxo‑guanosine triphosphate (8‑oxo‑rGTP) is incorporated by RNA polymerase II and how its pairing geometry with template bases (dC vs dA) differentially al... more
Wang Y et al et al., PNAS - This episode covers a PNAS study describing v96, a personalized plasma cell-free DNA assay that tracks up to 96 patient-specific mutations to sensitively quantify measurable residual disease (MRD) in AML patients before an... more
Holta KB et al., Proceedings of the National Academy of Sciences (PNAS) - This episode explains a quantitative framework for diffusion on spatially embedded dynamic mitochondrial networks. The study combines analytic theory, agent-based simulations, ... more
Kimchi O et al., PNAS - This computational study shows that self-complementary RNA regions (palindromes) can drive sequence-specific homotypic clustering by enabling multivalent intermolecular base pairing, and that Drosophila nanos and pgc mRNAs are... more
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Apple Podcasts | #165 |  United Kingdom/Science/Life Sciences |
Apple Podcasts | #203 |  Australia/Science/Life Sciences |
Apple Podcasts | #121 |  Singapore/Science/Life Sciences |
Apple Podcasts | #157 |  Japan/Science/Life Sciences |
Apple Podcasts | #159 |  Netherlands/Science/Life Sciences |
Apple Podcasts | #192 |  Brazil/Science/Life Sciences |
Apple Podcasts | #238 |  India/Science/Life Sciences |
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Frequently Asked Questions About Base by Base
What is Base by Base about and what kind of topics does it cover?
This show centers on advances in genetics and genomics, with a strong emphasis on how new studies translate to clinical understanding. Episodes commonly unpack topics like biobank biases, polygenic risk scores, transcriptional and regulatory mechanisms, genome-wide association methods, and the practicalities of implementing genomic insights in healthcare. Across installments, the hosts tend to connect methodological nuances to real-world implications—ranging from diagnostic yield and disease risk prediction to ethical considerations and health equity—often highlighting innovative analytic techniques (e.g., weighting schemes, NLP in clinical data, and population-specific reference resources) and the challenges of translating cutting-edge res... more
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Which podcasts are similar to Base by Base?
These podcasts share a similar audience with Base by Base:
1. Brain Talk | Being Patient for Alzheimer's Patients and Caregivers
2. Better Brain Fitness (a Brainjo Production)
3. The Smartest Doctor in the Room
4. The Longevity Podcast: Optimizing HealthSpan & MindSpan
5. The Optispan Podcast with Matt Kaeberlein
How many episodes of Base by Base are there?
Base by Base launched a year ago and published 352 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.
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What guests have appeared on Base by Base?
Recent guests on Base by Base include:
1. Jirko Kuhnisch
2. Kaneco Weaver
3. Ruby White
4. Christophe Pellefigues
5. Franca Ronchese
6. Olivier Lamiable
7. David Eccles
8. Research Team from Duke University
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