
Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical relevance—one base at a time. Powered by AI, Base by Base offers a new way to learn on the go. Special thanks to authors who publish under CC BY 4.0, maki... more
| Publishes | Daily | Episodes | 255 | Founded | 9 months ago |
|---|---|---|---|---|---|
| Number of Listeners | Categories | Life SciencesScienceMedicineHealth & Fitness | |||

Chen T et al., Nat Commun - Cryo-EM structures, uptake assays, and molecular dynamics show that PIP2 lipids bind at the AE1 dimer interface and inhibit the OF⇌IF conformational transition while substrate binding lowers the transition barrier. Key ter... more
Winterhalter et al., Rescuing the bacterial replisome at a nick requires recombinational repair and helicase reloading. Nat Commun ( - Cas9 nickases in Bacillus subtilis show that single-strand nicks in either template strand arrest DNA replication, ... more
Gao J et al., Nat Commun - H4 tail lysine residues drive liquid-liquid phase separation of 12‑mer nucleosome arrays, while H3 tail acetylation and the histone chaperone Nap1 increase internal dynamics and lower droplet viscosity. Key terms: Nap1, H3 ... more
️ Episode 252: Keratinocytes to cSCC: genetic steps
In this episode of PaperCast Base by Base, we explore Single-cell and spatial multi-omic profiling maps the genetic and transcriptional changes from normal keratinocytes through actinic keratoses ... more
How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.
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Apple Podcasts | #150 |
Recent interactions between the hosts and their guests.
Listeners, social reach, demographics and more for this podcast.
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Exploring the intricacies of genetics and genomics, this podcast provides insightful discussions on gene-disease associations, protein structure, and the implications of cutting-edge research in exome and genome sequencing. Each episode meticulously breaks down prominent studies, linking complex scientific concepts to their clinical relevance and practical applications. With a strong focus on recent advancements, the content is likely to resonate with listeners interested in how genetic factors play a crucial role in health and disease. The educational format is conducive for listeners eager to expand their knowledge on genetic science while on the move, making advanced topics accessible to a broad audience.
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Base by Base launched 9 months ago and published 255 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.
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Recent guests on Base by Base include:
1. Research Team from Duke University
2. Tianxin Zeng
3. Alan J. Aw
4. Marcus W. Feldman
5. Anna Axakova
6. Megan Ding
7. Jacques Fellay
8. Dr. Lucas da Silva
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