Rephonic
Artwork for 632nm
Quantum Computing
Quantum Error Correction
Artificial Intelligence
Nanotechnology
Semiconductors
Lithography
Quantum Dots
Extreme Ultraviolet Lithography
Photochemistry
Quantum Mechanics
Origins Of Life
193nm Lithography
248nm Lithography
Ig Nobel Prize
Neuroscience
Zapata Computing
Flux Fellowship
Gravitational Waves
Lasers
Computational Chemistry

Technical interviews with the greatest scientists in the world.

PublishesTwice monthlyEpisodes61Founded2 years ago
Number of ListenersCategories
Natural SciencesScience

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Artwork for 632nm

Latest Episodes

What is intelligence, and where does it come from?

Watch Part 1 here: youtu.be/t6EFV2gSSmg?si=VIztbK2CM5Nwj7QA

In this episode, Michael Levin, professor of biology at Tufts University, returns to discuss his research into unconventional int... more

Can AI help design personalized cancer vaccines?

Visit Future of Cancer Care Today: sijbrandijfoundation.org/fcct

In this episode, we speak with Sid Sijbrandij, founder of GitLab who went "Founder Mode" against his own cancer. Sid discusses... more

What does it actually take to build a quantum computer that can scale to millions of qubits?

Learn more about Qolab here: qolab.ai/

In this episode, we speak with John Martinis, recipient of the 2025 Nobel Prize in Physics. Martinis is a pi... more

What does a cell actually look like when you can see its molecules in action?

In this episode, we speak with Nobel Prize-winning scientist Eric Betzig, whose pioneering work in super-resolution microscopy transformed our ability to see inside living... more

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Recent Guests

Sid Sijbrandij
Co-founder of GitLab; cancer patient and biotech innovator
GitLab
Episode: AI, Cancer Vaccines, and the Future of Personalized Medicine | Sid Sijbrandij on GitLab + Biotech
John Martinis
Pioneer of superconducting quantum computing; founder of Qolab
Qolab
Episode: Building Quantum Computers at Semiconductor Scale | John Martinis on Qolab + Superconducting Qubits
Eric Betzig
Nobel Laureate, UC Berkeley professor who pioneered super-resolution microscopy
University of California, Berkeley
Episode: Diffraction Limit, Microscopy, and Cell Biology | Eric Betzig on Super-Resolution Microscopy
Yonatan Cohen
Co-founder and CTO of Quantum Machines
Quantum Machines
Episode: The Hybrid Architecture Behind Quantum Computing | Yonatan Cohen Quantum Machines CTO
Walter Gilbert
Nobel Prize–winning molecular biologist, co-developer of DNA sequencing methods, Biogen co-founder
Biogen
Episode: How DNA Sequencing Was Discovered By Accident | Walter Gilbert on Biogen, Industry, and Art
Michael Manson
Scientist/biophysicist discussing bacterial motility and flagellar motor research
Not explicitly stated in transcript
Episode: How Bacteria Evolved Rotary Motors | Michael Manson
Mark Saffman
Professor at the University of Wisconsin–Madison, pioneer in neutral atom quantum computing
University of Wisconsin–Madison
Episode: The Atomic Physics Behind Neutral Atom Computers | Mark Saffman
John Bowers
Professor at UC Santa Barbara; pioneer in silicon photonics
UC Santa Barbara
Episode: Silicon Photonics and the Future of AI Scaling | John Bowers
Mike Levin
Biophysicist specializing in bioelectric signals and morphogenesis
Tufts University (implied from context)
Episode: Bioelectricity, Morphogenesis, and Two-Headed Worms | Michael Levin

Hosts

Mike
Host of the podcast and interviewer
Misha Lukin
Co-host of the show

Reviews

4.9 out of 5 stars from 56 ratings
  • Great in depth chart btw reviews

    This podcast is fantastic. Really give their interviewees the space to discuss as though with their graduate students. I can’t always keep up but it’s always interesting to try

    Apple Podcasts
    5
    JCPerrin
    United States24 days ago
  • I would pay tuition for this podcast

    Thanks for such incredible conversations. Please keep it going.

    Apple Podcasts
    5
    NSolin
    United States7 months ago
  • Secrets of the universe/Deepest physics podcast

    Like if 3 blue 1 brown was doing three hour interviews with noble prize winners

    Apple Podcasts
    5
    midnightflutter
    United Statesa year ago
  • My favorite podcast!

    What an incredible, rich, amazing series. Bravo to the team ❤️

    Apple Podcasts
    5
    Anna 🦋 👩🏻‍🔬
    United States2 years ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Listeners appreciate the depth and rigor of conversations.
Guests are given space to explore complex ideas at length.
Audience feedback highlights high-quality, thoughtful interviews.
Show is praised for blending history, theory, and practical engineering insights.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Talking Points

Recent interactions between the hosts and their guests.

AI, Cancer Vaccines, and the Future of Personalized Medicine | Sid Sijbrandij on GitLab + Biotech
Q: What about the regulatory path for such personalized therapies?
Sid describes pathways like single-patient INDs and the potential for faster routes in some jurisdictions, noting that regulatory flexibility and ethical considerations are key to enabling access while ensuring patient safety.
AI, Cancer Vaccines, and the Future of Personalized Medicine | Sid Sijbrandij on GitLab + Biotech
Q: What are the main costs and bottlenecks when making a patient-specific vaccine?
He discusses the high manufacturing complexity, the need to tailor vaccines to individual tumor profiles, and the significant upfront investment to develop and produce doses for a single patient, which makes scaling difficult but advances are pushing costs down over time through learning effects.
AI, Cancer Vaccines, and the Future of Personalized Medicine | Sid Sijbrandij on GitLab + Biotech
Q: Why don't we have an mRNA vaccine yet for every disease?
Sid notes that while the technology is powerful, producing personalized vaccines is technically and logistically challenging; scale, manufacturing costs, and the need for disease-specific validation slow broad adoption, though melanoma shows promising signals.
AI, Cancer Vaccines, and the Future of Personalized Medicine | Sid Sijbrandij on GitLab + Biotech
Q: So Sid, just walk us through first principles, like soup to nuts. How do mRNA vaccines work and why do they work?
Sid explains that mRNA vaccines encode antigens specific to the cancer, delivered inside lipid nanoparticles; the design hinges on targeting cancer-specific signals, with many factors influencing success such as stability and avoiding healthy tissue. He emphasizes the complexity of design and the need for diverse expert input to optimize vaccines.
How DNA Sequencing Was Discovered By Accident | Walter Gilbert on Biogen, Industry, and Art
Q: What are your thoughts on sequencing genomes of babies and the ethical considerations involved?
sequencing holds potential for early intervention and personalized medicine, but requires careful consideration of ethics, access, data use, and insurance implications; public policy and health system incentives must align to ensure beneficial use without exploitation.

Audience Metrics

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Frequently Asked Questions About 632nm

What is 632nm about and what kind of topics does it cover?

A rigorous, high-signal interview series that foregrounds foundational science and advanced engineering. Across episodes, listeners encounter deep dives into quantum computing hardware, novel sensing technologies, cell biology, and cutting-edge computational approaches, often featuring Nobel laureates and leading researchers. The show stands out for unpacking intricate topics with candid anecdotes, practical engineering challenges, and long-form explorations of how breakthrough ideas transition from theory to scalable technology. Potential guests and sponsors can expect a highly technical audience that values clarity, rigor, and real-world impact in science and tech.

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Which podcasts are similar to 632nm?

These podcasts share a similar audience with 632nm:

1. Dwarkesh Podcast
2. The Quanta Podcast
3. Manifold
4. The Joy of Why
5. Big Brains

How many episodes of 632nm are there?

632nm launched 2 years ago and published 61 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on 632nm?

Recent guests on 632nm include:

1. Sid Sijbrandij
2. John Martinis
3. Eric Betzig
4. Yonatan Cohen
5. Walter Gilbert
6. Michael Manson
7. Mark Saffman
8. John Bowers

To view more recent guests and their details, simply upgrade your Rephonic account. You'll also get access to a typical guest profile to help you decide if the show is worth pitching.

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