Rephonic
Artwork for 21 in 21
Bitcoin
Artificial Intelligence
Block
Lightning Network
Goose
Spiral
Quantum Computing
Bitcoin Design Community
Bitcoin Design Foundation
Bitcoin Core
Hack Nation
Local AI
Presidio Bitcoin
Open Source AI
Open Source
Delving
Freedom Of the Press Foundation
Mesh LLM
Privacy
Money Dev Kit

Haley Berkoe asks some of the biggest names in bitcoin and Silicon Valley 21 questions in 21 minutes, from the personalities you know and love to tech’s unsung heroes. A new episode drops when someone stops by Presidio Bitcoin. Reach out if you are or will be in the area and are interested in being on the show. presidiobitcoin.substack.com

PublishesTwice monthlyEpisodes39Foundeda year ago
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Artwork for 21 in 21

Latest Episodes

0xSero joins Haley Berkoe on 21 in 21 to discuss local AI, open models, and his soon-to-be-released platform for benchmarking open models and hardware (local.ai). He explains how his team benchmarks models and hardware, why local AI is becoming more ... more

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Haley Berkoe sits down with Bradley Axen, who is leading many of Block's AI initiatives, including Buzz, a new open-source collaboration platform designed for humans and AI agents to work together. He also helped create goose, the open-source AI agen... more

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Mic Neale, a member of the Spiral team at Block and a core developer of goose, an open source AI agent, joins Haley Berkoe on 21 in 21 to discuss goose, Mesh LLM, and open source AI. Mic shares how goose has evolved from a desktop app and CLI into th... more

YouTube

Patrick Ball, Director of Research at the Human Rights Data Analysis Group, joins Haley Berkoe on 21 in 21 to discuss how data, bitcoin, and AI can help defend human rights. Patrick explains how his team uses statistics to document mass violence, how... more

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Recent Guests

Sharif (0xSero)
AI researcher/engineer focused on local AI and open-source tooling
Local AI / 0xSero
Episode: 21 in 21: 0xSero on Local AI, Open Models, and Benchmarking
Bradley Axen
Lead AI efforts at Block; creator of Goose; involved in AI tooling and open-source initiatives
Block
Episode: 21 in 21: Bradley Axen on Buzz, goose, and AI at Block
Mic Neale
Open source AI advocate, co-founder involved with Goose and Mesh LLM
Goose; Block; Spiral
Episode: 21 in 21: Mic Neale on goose, Mesh LLM, and Open Source AI
Patrick Ball
Statistician focusing on mass violence data analysis
Human Rights Data Analysis Group (HRDAG)
Episode: 21 in 21: Patrick Ball on Using Bitcoin and AI to Defend Human Rights
Linn Bieske
Product manager for AI research and AI foundation
MIT
Episode: 21 in 21: Linn Bieske on Hack-Nation and Building Global AI Communities
Rainey Reitman
Civil liberties advocate; cofounder of Freedom of the Press Foundation, former EFF staff
Freedom of the Press Foundation; Electronic Frontier Foundation
Episode: 21 in 21: Rainey Reitman on Transaction Denied and Financial Censorship
Michael Saylor
CEO of MicroStrategy and prominent Bitcoin advocate
MicroStrategy
Episode: 21 in 21: Michael Saylor on Bitcoin, AI, and Advice for Builders
Andi Pitt
Founding partner at Ego Death Capital, a Bitcoin-only venture fund
Ego Death Capital
Episode: 21 in 21: Andi Pitt on Bitcoin Venture, AI, and Cognitive Sovereignty
Mark Suman
CEO and co-founder of Maple AI
Maple AI
Episode: 21 in 21: Mark Suman on Privacy-First AI

Host

Haley Berkoe
Host of the show; guides interviews and introduces guests; Presidio Bitcoin

Reviews

4.8 out of 5 stars from 6 ratings
  • Go Bay Area

    Saylor

    Apple Podcasts
    5
    Eric Seneca Kim
    United States5 months ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Guests bring practical, startup-friendly perspectives that translate into actionable insights for developers and merchants.
Listeners appreciate candid, future-focused conversations with top Bitcoin and tech figures.
The host's industry connections and clear focus on open-source and privacy are consistently highlighted by fans.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Apple Podcasts
#114
Colombia/Technology
Apple Podcasts
#119
Belgium/Technology

Talking Points

Recent interactions between the hosts and their guests.

21 in 21: Bradley Axen on Buzz, goose, and AI at Block
Q: Can you tell me a little bit what led you down that path?
Brad discusses joining Block's ML and data platform during the AI scaling moment, experimenting with LLMs to automate internal workflows, and eventually leading to Goose as an internal tool that later became open source, shaping his broader AI strategy at Block.
21 in 21: 0xSero on Local AI, Open Models, and Benchmarking
Q: What initially sparked your interest in AI, specifically local AI?
Sharif explains a transition from crypto and open-source work to local AI, motivated by the desire for ownership, cost control, and understanding how models operate under the hood, which led to building Local AI and benchmarking hardware.
21 in 21: Kyle Olney
Q: What is the main goal with Save Our Wallets and the Satoshi Needs You campaign, and how do you see the legislation affecting self-custody and open-source software?
The goal is to ensure BRCA language is included in the final market structure bill to confirm non-custodial, open-source software isn't treated as money transmitters, thereby protecting self-custody and discouraging centralized overreach; the campaigns also aim to educate and mobilize Bitcoiners to participate in the legislative process.
21 in 21: Kyle Olney
Q: Kyle, can you just tell us a little bit about your journey from tech into Bitcoin and what led you to do this advocacy work?
Kyle describes a round-trip career path: he started in government during the financial crisis, moved into tech, became an early advocate for Bitcoin, and then returned to focus on Bitcoin policy and advocacy after years in Silicon Valley startups.
21 in 21: Alex Gladstein
Q: What do you see as the ideal role of government in a Bitcoin-enabled world?
Gladstein envisions government as a people-powered institution that should protect rights and mediate disputes, with stronger local governance and less central bureaucracy, enabling safer and freer societies.

Audience Metrics

Listeners, social reach, demographics and more for this podcast.

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Frequently Asked Questions About 21 in 21

What is 21 in 21 about and what kind of topics does it cover?

A short-form interview series features high-profile figures from Bitcoin, tech, and Silicon Valley answering 21 rapid questions in about 21 minutes. Conversations span Bitcoin adoption, AI intersections, developer tooling, and community-building, with a consistent thread of practical, real-world impact—from merchant adoption to open-source projects and design-focused UX. The format tends to surface bold visions for digital money, privacy-preserving tech, and the ways builders can turn ideas into products quickly, making complex topics accessible for practitioners and enthusiasts alike. Noteworthy is the recurring emphasis on hands-on projects, open collaboration, and a bias toward actionable takeaways for developers, founders, and merchants... more

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1. PBJ
2. Rabbit Hole Recap
3. TFTC: A Bitcoin Podcast
4. What Bitcoin Did
5. Coin Stories with Natalie Brunell

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21 in 21 launched a year ago and published 39 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on 21 in 21?

Recent guests on 21 in 21 include:

1. Sharif (0xSero)
2. Bradley Axen
3. Mic Neale
4. Patrick Ball
5. Linn Bieske
6. Rainey Reitman
7. Michael Saylor
8. Andi Pitt

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