The Lancet Gastroenterology & Hepatology in conversation with

The Lancet Group

Inflammatory Bowel Disease

Crohn's Disease

Colorectal Cancer

Quality Of Life

Hepatitis B

Irritable Bowel Syndrome

Low FODMAP Diet

Low Carbohydrate Diet

Pharmacological Treatments

Car-Ibs Trial

Colonoscopy

Intestinal Ultrasound

ASCOLT Trial

Acute Kidney Injury

Decompensated Cirrhosis

Liver Stiffness Measurement

Peth Biomarker

Steatotic Liver Disease

Liverscreen Study

Sub-Saharan Africa

Hugh Thomas, Deputy Editor at The Lancet Gastroenterology & Hepatology, in conversation with the journal’s authors, explores their latest research and its impact on people’s health, healthcare, and health policy.A monthly audio companion to the journal, this podcast covers a broad range of topics, from predicting clinical outcomes in NAFLD to immunosuppressant withdrawal in patients with Crohn’s d... more

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Publishes	Monthly	Episodes	87	Founded	6 years ago
Number of Listeners		Categories	MedicineHealth & Fitness

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Guests Host Charts Talking Points

Latest Episodes

Pere Ginès on long-term liver stiffness measurement as a screening tool for liver fibrosis

Could repeated liver stiffness measurement offer a practical approach to population-based liver fibrosis screening? In this episode, we speak with Pere Ginès about the LiverScreen study, which analysed changes in liver stiffness over time across thre... more

11 Sep 2026 • 19 min • Most popular

Frank Ruemmele on a trial of cyclic exclusive enteral nutrition versus partial enteral nutrition to maintain remission in paediatric Crohn's disease

In children with Crohn’s disease who achieve remission through exclusive enteral nutrition, what's the optimal dietary therapy to maintain remission without the use of medication or surgery? Frank Ruemmele (Université Paris Cité) talks through the CD... more

13 Aug 2026 • 22 min

Aleksander Krag on the utility of PEth for subclassifying individuals at risk of steatotic liver disease

Steatotic liver disease labels hinge on alcohol intake, but self-report is often inaccurate. In this episode, Aleksander Krag (Odense University Hospital) discusses a large Danish study using phosphatidylethanol (PEth), a direct blood biomarker of re... more

23 Feb 2026 • 20 min

Dina Kao on a trial of lyophilised sterile faecal filtrate versus lyophilised conventional donor stool for recurrent Clostridiodes difficile infection

Can bacteria-free, sterile faecal filtrate match conventional faecal microbiota transplantation for recurrent C difficile infection? Dina Kao (University of Alberta) unpacks a landmark multicentre trial that tested this hypothesis, and we discuss wha... more

28 Nov 2025 • 15 min

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Recent Guests

Pere Ginès

Professor, Liver Unit Hospital Clinic Barcelona, University of Barcelona

Liver Unit Hospital Clinic Barcelona; University of Barcelona

Episode: Pere Ginès on long-term liver stiffness measurement as a screening tool for liver fibrosis

Frank Ruemmele

Professor of Pediatrics at Université Paris Cité and Head of Pediatric Gastroenterology & Nutrition at Necker-Enfant-Millard Hospital, Paris

Université Paris Cité / Necker-Enfant-Millard Hospital

Episode: Frank Ruemmele on a trial of cyclic exclusive enteral nutrition versus partial enteral nutrition to maintain remission in paediatric Crohn's disease

Aleksander Krag

Corresponding author on the study; Professor and Department Chair at Odense University Hospital

Odense University Hospital, Center for Liver Research

Episode: Aleksander Krag on the utility of PEth for subclassifying individuals at risk of steatotic liver disease

Dina Kao

Professor of Medicine focused on therapeutic manipulation of the gut microbiome and FMT for recurrent C. diff

University of Alberta

Episode: Dina Kao on a trial of lyophilised sterile faecal filtrate versus lyophilised conventional donor stool for recurrent Clostridiodes difficile infection

Premic Bercik

Professor of Medicine and Gastroenterology at McMaster University

McMaster University

Episode: Premysl Bercik on a double-blind crossover trial of gluten and wheat in IBS

Dr. Salvatore Piano

Associate Professor of Internal Medicine and Consultant Hepatologist

University and Hospital of Padua, Italy

Episode: Salvatore Piano on the global epidemiology of acute kidney injury in hospitalised patients with decompensated cirrhosis

John Chia

Consultant medical oncologist at Curie Oncology; formerly chief of gynecology oncology service at the National Cancer Centre Singapore

Curie Oncology

Episode: John Chia on the ASCOLT trial of adjuvant aspirin for colorectal cancer

Professor Hannes Hagström

Consultant in Hepatology at the Karolinska University Hospital and professor with a research focus on liver disease epidemiology.

Karolinska Institute

Episode: Hannes Hagström on screening for advanced liver fibrosis alongside retina scanning in people with type 2 diabetes

Dr. Cathy Lu

Associate Professor at the University of Calgary and first author of the consensus statement.

University of Calgary

Episode: Cathy Lu on intestinal ultrasound for assessing and monitoring Crohn’s disease small bowel strictures

Host

Hugh Thomas

Deputy Editor at The Lancet Gastroenterology & Hepatology

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Apple Podcasts	#131	Australia/Health & Fitness/Medicine
Apple Podcasts	#76	Sweden/Health & Fitness/Medicine
Apple Podcasts	#146	Switzerland/Health & Fitness/Medicine
Apple Podcasts	#170	India/Health & Fitness/Medicine
Apple Podcasts	#200	South Korea/Health & Fitness/Medicine
Apple Podcasts	#212	Japan/Health & Fitness/Medicine
Apple Podcasts	#242	Russia/Health & Fitness/Medicine

Talking Points

Recent interactions between the hosts and their guests.

Frank Ruemmele on a trial of cyclic exclusive enteral nutrition versus partial enteral nutrition to maintain remission in paediatric Crohn's disease

Q: What was the rationale behind choosing cyclic exclusive enteral nutrition as the primary intervention compared with partial enteral nutrition?

The researchers aimed to test whether intermittent complete reliance on enteral nutrition could sustain remission without drugs, given that induction with exclusive nutrition is effective but drugs are typically used for maintenance; they also sought a feasible comparator that would reflect real-world adherence without a placebo.

Aleksander Krag on the utility of PEth for subclassifying individuals at risk of steatotic liver disease

Q: Can you run us through the triage algorithm and explore how it might be deployed clinically?

The host and guest describe a three-tiered approach: start with self-report and AUDIT-C, then use PATH testing for discordant or ambiguous cases, potentially reducing PATH use by about 40% in suitable patients.

Aleksander Krag on the utility of PEth for subclassifying individuals at risk of steatotic liver disease

Q: What participants were you including in this study? How were you defining the self-reported intake and the AUDIT-C and collecting that information?

The guest explains a large prospective Danish cohort including individuals with cardiometabolic risk factors, using standardized questionnaires for self-report and AUDIT-C, alongside Peth measurements.

Aleksander Krag on the utility of PEth for subclassifying individuals at risk of steatotic liver disease

Q: To kick things off then, for our listeners who don't necessarily work with steatotic liver disease and its various subclassifications every day, how is alcohol exposure currently used to distinguish between MASLD or META-LD or ALD, and why does getting that subclassification right matter?

The doctor outlines that classification is based on self-reported alcohol consumption, with thresholds that separate MASLD, META-LD, and ALD, emphasizing that accurate subclassification guides targeted treatment and prognosis.

Dina Kao on a trial of lyophilised sterile faecal filtrate versus lyophilised conventional donor stool for recurrent Clostridiodes difficile infection

Q: What do the results imply about the role of live microbes in FMT efficacy?

Results suggest live bacteria contribute significantly to efficacy, as the filtrate showed high short-term success but was not non-inferior to donor stool, and microbiome analyses revealed donor-like shifts and recovery of beneficial taxa predominantly in the conventional FMT group, indicating live microbes may be essential for full therapeutic effect.

Audience Metrics

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Frequently Asked Questions About This Podcast

What is This Podcast about and what kind of topics does it cover?

This series features in-depth discussions on pivotal research and breakthroughs in gastroenterology and hepatology, focusing on their implications for healthcare and health policy. Episodes cover diverse topics, from advanced liver disease management strategies to innovations in inflammatory bowel disease treatment and antibiotic resistance. Noteworthy is a strong emphasis on both clinical practice and patient-centered approaches, aiming to bridge the gap between research findings and real-world applications in healthcare settings.

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1. JAMA Clinical Reviews
2. 7 minute Hepatology
3. NEJM This Week
4. JAMA Medical News
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this podcast launched 6 years ago and published 87 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on this podcast?

Recent guests on this podcast include:

1. Pere Ginès
2. Frank Ruemmele
3. Aleksander Krag
4. Dina Kao
5. Premic Bercik
6. Dr. Salvatore Piano
7. John Chia
8. Professor Hannes Hagström

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