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Talk Python To Me

Michael Kennedy
Python
Data Science
Machine Learning
Django
Fastapi
Pydantic
Web Development
Large Language Models
Pandas
Open Source
Flask
Rust
Marimo
Jupyter Notebooks
Natural Language Processing
Cpython
Cloud Computing
Data Analysis
Open Source Software
Web Applications

Talk Python to Me is a weekly podcast hosted by developer and entrepreneur Michael Kennedy. We dive deep into the popular packages and software developers, data scientists, and incredible hobbyists doing amazing things with Python. If you're new to Python, you'll quickly learn the ins and outs of the community by hearing from the leaders. And if you've been Pythoning for years, you'll learn about ... more

PublishesWeeklyEpisodes563Founded12 years ago
Number of ListenersCategory
Technology

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Artwork for Talk Python To Me

Latest Episodes

Every ship in EVE Online eventually undocks and leaves the station. This time, it's the whole game. EVE has run on Python 2 since it launched in 2003, all 2.4 million lines of it, on a custom Stackless interpreter that stopped at 3.8 and was archived... more

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Lint the entire CPython code base from scratch. It takes 0.3 seconds. Three blinks of an eye.

That is ruff, and it is written in Rust. So are Pydantic, Polars, uv, and Granian. Rust shows up in Python three ways: tools that happen to be Rust, lib... more

YouTube

How many files does your query read before it reads any data? On some data lakes, you go through JSON and metadata files first, just to learn which Parquet files matter. DuckLake asks one SQL question instead. The metadata lives in a real database. T... more

YouTube

How many cores does your machine have, 10, 18? Your async Python code uses just one of them. That isn't a bug in asyncio. That's the design, and optimizing event loops to be faster by 20% doesn't change it. So Giovanni Barillari started over. Joe is ... more

YouTube

Key Facts

Accepts Guests
Accepts Sponsors
Contact Information
Podcast Host
Number of Listeners
Find out how many people listen to this podcast per episode and each month.

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Recent Guests

Pedro Holanda
Lead Duck Lake developer; co-creator background in DuckDB at CWI
DuckDB team at CWI
Episode: #562: DuckLake: The Lakehouse That's Just SQL and Parquet
Guillermo Sanchez-Doinas
Developer/engineer contributing to Duck Lake and Quack
Duck Lake team
Episode: #562: DuckLake: The Lakehouse That's Just SQL and Parquet
Giovanni Bariliari
Creator of Tonio, Tonio runtime lead
Tonio project
Episode: #561: TonIO, a Multi-threaded Async Runtime for Python
Sean Chua
Gastroenterologist and clinical researcher
University of Glasgow, GUT Translational Research Group
Episode: #560: Building a Research OS: From Django to 30,000 Samples
Matt Lea
AWS consultant and founder of schematical.com; creator of Cloud War Games
schematical.com
Episode: #559: 12 Things You Should (and Shouldn't) Do in AWS
Michael Booth
Data Booth founder, former computational chemist and data consultant
Data Booth
Episode: #558: Hyper-Personal Software with Python
Juanita Gomez
CPython Core Developer; PhD Researcher in open-source security at UC Santa Cruz
UC Santa Cruz; Python Software Foundation
Episode: #557: Security of everything at PyCon 2026
Seth Larson
Security Developer in Residence at the Python Software Foundation
Python Software Foundation
Episode: #557: Security of everything at PyCon 2026
Mike Fiedler
PyPI Safety and Security Engineer
Python Software Foundation
Episode: #557: Security of everything at PyCon 2026

Host

Michael Kennedy
Host of Talk Python To Me; long-time Python developer and entrepreneur

Reviews

4.8 out of 5 stars from 1.2k ratings
  • Great to hear from experts

    I love how Michael gets different experts on the show to share their expertise. In a world where I don’t always trust what Google AI overview is telling me it’s fantastic to hear from real humans.

    Apple Podcasts
    5
    Adam_____7
    Australiaa month ago
  • Love the show hate the intro

    I love the show and the content. The new intro, however, makes me want to throw my phone out the window every time I hear it. It literally makes me want to stop listening to the podcast episode.

    Apple Podcasts
    4
    Agandgold
    United Statesa year ago
  • Eh

    Dropped this podcast after the Temporal episode, which seemed to be mostly complaining about Twitter and people who self-host, rather than pay for the guest’s employer’s managed service. More informative talks, less poorly disguised sales pitches couched in a lot of strange bitterness, please.

    Apple Podcasts
    2
    Thank T.
    United Statesa year ago
  • leftist/democrat morons

    He has no problem with Twitter and all fascist commie democrats’ activist tech political censorship, lying, election interference, etc, but Twitter bought by Elon Musk, OH NO! Absolute dishonesty and delusion to claim you like mastodon for open ness, when all of you were fine with fascist/commie democrat twitter and all tech bias. Very transparent. Very dumb.

    Apple Podcasts
    1
    MnReview
    United Statesa year ago
  • Great Resource

    I really enjoy this series, the host has great guests with unique but applicable perspectives. As a novice data-doer i love hearing about the potential applications of different tech tools.

    Apple Podcasts
    5
    Iamnotarobot0101001
    United States2 years ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Great mix of guests from security to tooling.
High-quality production and thoughtful topics.
Listener-friendly explanations make complex topics accessible.
Consistently valuable for staying up-to-date in Python ecosystem.
Excellent interviews with deep Python expertise.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Apple Podcasts
#225
United States/Technology
Apple Podcasts
#236
Canada/Technology
Apple Podcasts
#147
Germany/Technology
Apple Podcasts
#73
Philippines/Technology
Apple Podcasts
#78
India/Technology
Apple Podcasts
#128
Finland/Technology

Talking Points

Recent interactions between the hosts and their guests.

#563: Getting Started with Rust as Python Devs
Q: What are the main ways Rust intersects with Python today, and where do you see the biggest wins for Python developers?
Three modes: (1) Rust-powered tools that Python uses indirectly (like Ruff for linting); (2) Rust extensions loaded into Python to accelerate critical paths (with PyO3 and maturin); and (3) embedding Python inside a Rust program for performance-critical servers. The biggest wins are substantial speedups for data processing and heavy computation, improved memory safety in critical libraries, and a packaging story that lets Python users access high-performance crates with minimal changes to their Python code.
#563: Getting Started with Rust as Python Devs
Q: Now, I want to start by talking about Rust. Just some examples before we dive into how is it compared to Python. We've touched on a little bit of that, but there's a bunch of differences and so on. What are the big picture differences for a Python developer?
We discussed how Rust is a compiled, low-level language with strict memory management, which trades some upfront friction for stronger guarantees and faster runtime. We covered the borrow checker, compile-time checks, and how Python's dynamic, garbage-collected model contrasts with Rust's explicit ownership and memory safety. We also touched on how Python can leverage Rust via PyO3 and how tooling like cargo and crates.io shape Rust development compared to Python's pip and PyPI.
#554: Trustworthy AI in Healthcare and Longevity
Q: Okay, and how did you get into the AI side of things?
The guest explains the shift from data analysis to AI-enabled execution, driven by the need to prepare for roles that AI wouldn't replace, especially after witnessing rapid model advancement during the COVID era and the fear of layoffs.
#552: Astral joins OpenAI
Q: What was OpenAI primarily interested in regarding Charlie's tooling?
OpenAI was interested in a combination of Python tooling and Rust work, with a focus on accelerating OpenAI as a user of the tools, and rethinking how the tools fit into a broader platform that can support agents and human developers alike.
#546: Self hosting apps for Python people
Q: What role does Tailscale play in self-hosted infrastructure?
Tailscale provides zero-port, end-to-end connectivity by creating a secure mesh network, enabling direct access to home servers from any location without exposing ports publicly.

Audience Metrics

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Frequently Asked Questions About Talk Python To Me

What is Talk Python To Me about and what kind of topics does it cover?

A tech-focused podcast that dives deep into Python tooling, ecosystems, and real-world engineering practices. Episodes frequently center on open-source projects, security, AI-assisted development, cloud infrastructure, and software architecture, with guests ranging from maintainers and founders to researchers and practitioners. Listeners are likely software engineers, data scientists, and tech leads who want concrete takeaways, best practices, and context from practitioners actively shaping the Python and broader developer landscape. A notable strength is the steady stream of high-signal guests who are hands-on contributors to widely used tools and frameworks, offering practical insights applicable to day-to-day work and strategic tech deci... more

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Which podcasts are similar to Talk Python To Me?

These podcasts share a similar audience with Talk Python To Me:

1. The Real Python Podcast
2. Python Bytes
3. Software Engineering Radio - the podcast for professional software developers
4. The Stack Overflow Podcast
5. Syntax - Tasty Web Development Treats

How many episodes of Talk Python To Me are there?

Talk Python To Me launched 12 years ago and published 563 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on Talk Python To Me?

Recent guests on Talk Python To Me include:

1. Pedro Holanda
2. Guillermo Sanchez-Doinas
3. Giovanni Bariliari
4. Sean Chua
5. Matt Lea
6. Michael Booth
7. Juanita Gomez
8. Seth Larson

To view more recent guests and their details, simply upgrade your Rephonic account. You'll also get access to a typical guest profile to help you decide if the show is worth pitching.

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