聊聊Sci
淼淼Elva聊聊Science和Nature！
| Publishes | Daily | Episodes | 535 | Founded | 8 months ago |
|---|---|---|---|---|---|
| Language | Norwegian | Number of Listeners | Category | Science |
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Latest Episodes
这项研究揭示了右侧前内侧眶额皮层（amOFC）的低频伽马射线动力学是强迫症（OCD）症状波动的关键神经生物学标志物。通过对三名难治性强迫症患者进行颅内监测，研究人员发现该区域的脑电能量会随着症状诱发同步上升。实验证明，对腹侧基底节（NAc-VeP）实施深部脑刺激（DBS）不仅能显著降低这种异常的伽马波能量，还能即时缓解患者的痛苦感。这一发现为开发个性化、闭环式的神经调控疗法提供了科学依据，旨在通过实时监测脑电特征来实现更精准的治疗。该成果标志着精神疾病治疗正从传统持续刺激向基于生物标志物驱动的精... more
这项研究揭示了十字花科植物中一种名为系统性气孔免疫（SSIM）的快速防御机制。当叶片遭受病原菌侵染时，受感染部位会产生一种由uORF编码的小肽——系统性气孔免疫导体（USIC）。USIC通过韧皮部进行远距离运输，并由未受感染叶片中的SIRK1-KIN7受体复合物感知。这种感知诱导了MC4蛋白酶对KIN7的切割及亚细胞易位，进而激活AHA1质子泵和PIP2;1水通道蛋白。最终，这一信号通路协同作用促使全株气孔关闭，从而在物理层面阻断病原菌进入。这一机制不仅弥补了系统获得性抗性（SAR）启动缓慢的不... more
这份研究报告介绍了一个交互式溶脑蛋白图谱，旨在揭示不同脑细胞类型中溶酶体的蛋白质组成差异。研究团队利用溶酶体免疫纯化技术（LysoIP）从神经元、星形胶质细胞、少突胶质细胞和小胶质细胞中提取溶酶体，并结合质谱分析鉴定出具有细胞特异性的蛋白质组。实验重点探讨了糖转运蛋白 SLC45A1 的功能，发现其在维持神经元溶酶体酸碱平衡和代谢稳态中起着至关重要的作用。通过对 Slc45a1 基因敲除小鼠及人类细胞模型的研究，作者证实了该转运蛋白缺失会导致代谢功能障碍和氧化应激。此外，该项工作还提供了公开的在... more
这项研究开发了一种名为 RePhyNERX 的新型液体活检技术，旨在提高膀胱癌患者尿液检测的准确性。研究人员发现，随着年龄增长，健康人尿液中也会出现类似癌症的基因突变，这种“场效应”往往会导致传统检测出现假阳性。通过对比肿瘤、正常组织及术后尿液，该方法能有效过滤非癌症干扰信号，精准识别微小残留病灶。在临床验证中，该技术成功将患者划分为手术反应者、BCG 免疫治疗反应者和无反应者三类。研究进一步揭示，肿瘤突变负荷（TMB）和预存的免疫炎症特征是预测 BCG 疗效的关键指标。这一成果为膀胱癌的个性化... more
Reviews
- 我最喜欢的播客之一，谢谢淼淼Elva
One of my favorite podcasts, thanks, 淼淼Elva
Apple Podcasts5TylerZou
China4 months ago - AI生成播客
选题挺好，真人聊就好了
Apple Podcasts1Yuantai SunChina5 months ago
Chart Rankings
How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.
Apple Podcasts | #36 | China/Science |
Apple Podcasts | #81 |  Hong Kong/Science |
Apple Podcasts | #238 |  Taiwan/Science |
Audience Metrics
Listeners, social reach, demographics and more for this podcast.
| Listeners per Episode | Gender Skew | Location | |||
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| Interests | Professions | Age Range | |||
| Household Income | Social Media Reach | ||||
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