聊聊Sci
淼淼Elva聊聊Science和Nature！
| Publishes | Daily | Episodes | 124 | Founded | 3 months ago |
|---|---|---|---|---|---|
| Language |  Vietnamese | Category | Science | ||
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这篇文章深入分析了通过整合生物技术和人工智能（AI）创新来改善农作物的策略，以满足全球人口增长对粮食、服装和其他重要产品的需求。文章详细探讨了组学技术、基因组编辑、蛋白质设计和高通量表型分析（HTP）的综合应用，这些都得益于AI工具的赋能。来源讨论了这些技术的新兴应用、当前挑战以及如何将通过这些技术产生的优良等位基因，在AI模型的辅助下，整合到现有或**从头驯化（de novo domesticated）**的作物基因组中。最终，作者提出将这些技术与农业实践相结合，将带来一场新的作物改良革命，从... more
这篇文章探讨了胸腺上皮细胞（mTECs）中的细胞可塑性机制，这种可塑性对免疫耐受的建立至关重要。研究人员发现，背景染色质可及性波动的放大（称为“表观遗传噪音”）促使mTECs异位表达通常限于其他组织的基因。这种噪音与肿瘤抑制因子p53的抑制相关，而增强p53活性则能稳定染色质，限制细胞可塑性，但同时也导致了多器官自身免疫。此外，染色质可及性噪音被发现与富含AT的基因组序列以及DNA损伤和转录起始的增加有关，突显了p53间接调控染色质稳定性以维持免疫功能的作用，并在肺腺癌（LUAD）模型中进一步证... more
这篇研究使用数据驱动的卫星图像分析来绘制全球陆地表面物候（LSP）图，即地球植被年生长节奏的地理模式。作者旨在克服现有方法在表示复杂物候方面的局限性，特别是干旱和热带生态系统中的复杂物候，并利用新的遥感指标（如近红外植被反射率，NIRV）来提供全球一致的LSP多样性见解。研究发现，热带山脉和地中海气候区是物候异步性的热点地区，这种异步性主要由降水和最低温度的异步性驱动。最终，研究表明这种遥感方法可以预测开花物候和遗传分化中的异地异步现象，证实了LSP作为理解生态和进化动态的关键工具的价值。
R... more
这篇文章讨论了肿瘤对造血系统的全身性影响，特别是肿瘤衍生的信号如何在骨髓早期重编程中性粒细胞，赋予它们免疫抑制特性，并提出阻断 IL-1β 可以作为逆转这种病理重编程和减少癌症转移的潜在治疗策略。
References:
• Dong L, Ng L G. Tumor neutrophils rewired from birth[J]. Cancer Cell, 2025.
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Apple Podcasts | #17 |  China/Science |
Apple Podcasts | #28 |  Hong Kong/Science |
Apple Podcasts | #153 |  Singapore/Science |
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聊聊Sci launched 3 months ago and published 124 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.
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