聊聊Sci
淼淼Elva聊聊Science和Nature！
| Publishes | Daily | Episodes | 1345 | Founded | a year ago |
|---|---|---|---|---|---|
| Language |  ZH-CN | Number of Listeners | Category | Science |
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Latest Episodes
这组研究揭示了SOAT1酶在肝细胞癌（HCC）免疫逃逸与术后复发中的核心驱动作用。通过对临床样本的蛋白组学分析，研究者发现SOAT1高表达与患者预后不良及免疫治疗耐药显著相关。在机制上，抑制该酶会增加内质网胆固醇含量，进而干扰SREBP代谢通路，削弱肿瘤细胞在免疫攻击下的氧化还原韧性。实验证明，利用药物或基因手段靶向SOAT1能显著增强CD8+ T细胞的杀伤效率，并提升PD-1抑制剂与CAR-T疗法的抗肿瘤效果。该研究为预防肝癌复发和优化肥胖相关肿瘤的免疫治疗提供了关键的代谢新靶点。
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这项研究揭示了慢性压力如何通过一种复杂的“噬菌体-成纤维细胞-B细胞”轴来削弱抗肿瘤免疫并加速癌症进展。长期压力会破坏肠道屏障，使特定的肠道病原菌（如Enterococcus gallinarum）发生易位并进入肿瘤内部。在肿瘤微环境中，这些细菌释放的噬菌体DNA通过TLR9受体激活肿瘤相关成纤维细胞，诱导其产生局部糖皮质激素。这种局部高水平的激素会直接抑制肿瘤内的生发中心B细胞反应，导致抗肿瘤抗体减少，从而形成有利于肿瘤生长的环境。研究进一步指出，通过靶向肠道细菌或阻断TLR9信号通路，可以恢... more
这项研究通过建立包含37个样本的慢性胰腺炎患者源性类器官（PDO）生物库，揭示了该疾病在分子水平上的复杂性。研究人员利用多组学和功能分析技术，鉴定出三种与发病原因无关的独立分子亚型，并发现这些类器官保留了上皮细胞内在的炎症特征。实验重点探讨了CFTR基因突变对导管功能的影响，证实了功能受损会导致运输障碍及炎症信号增强。通过使用CFTR调节剂，研究成功修复了受损类器官的导管功能，并有效降低了促炎和促有丝分裂信号。该成果为针对不同遗传背景的慢性胰腺炎患者开发精准医疗方案提供了重要的实验模型和理论依据... more
这项研究介绍了一种名为皮质脊髓疼痛强度模式 (CsPIP) 的新型神经影像生物标志物。研究人员通过同步采集大脑和脊髓的fMRI数据，开发出一个能整合全神经轴活动的多元预测模型，旨在更精准地解码人类的疼痛感知。实验结果表明，该模型的预测准确性显著优于传统仅关注大脑的指标，并能有效泛化至电刺激疼痛等不同维度。此外，CsPIP 成功追踪了经皮电刺激神经疗法产生的镇痛效果，展现了其作为治疗评价工具的潜力。在临床应用方面，该模型能够通过静态和动态的神经活动分析，预测慢性疼痛（如肠易激综合征）的严重程度及康... more
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Reviews
- 很好👍
做实验的时候听一听蛮好
Apple Podcasts5nothingppChina4 months ago - 我最喜欢的播客之一，谢谢淼淼Elva
One of my favorite podcasts, thanks, 淼淼Elva
Apple Podcasts5TylerZouChina9 months ago - AI生成播客
选题挺好，真人聊就好了
Apple Podcasts1Yuantai SunChina10 months ago
Chart Rankings
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Apple Podcasts | #35 | China/Science |
Apple Podcasts | #195 |  Hong Kong/Science |
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| Listeners per Episode | Gender Skew | Location | |||
|---|---|---|---|---|---|
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| Household Income | Social Media Reach | ||||
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聊聊Sci launched a year ago and published 1345 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.
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