聊聊Sci
淼淼Elva聊聊Science和Nature！
| Publishes | Daily | Episodes | 224 | Founded | 5 months ago |
|---|---|---|---|---|---|
| Language | Norwegian | Category | Science | ||
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这篇文章介绍了一个名为 HippoMaps 的开放获取工具箱和在线数据仓库，旨在为人类海马体提供多尺度绘图和背景化分析。HippoMaps 利用统一的海马体展开方法和形状内在配准能力，聚合了来自不同模态和尺度的海马数据，包括 3D离体组织学、超高场 MRI（9.4-T 和 7-T）、体内结构和静息态功能MRI，以及癫痫患者的 颅内脑电图 (iEEG) 记录。这项工作旨在提供一个标准化的框架，以比较不同方法得出的海马特征，探索结构与功能的关系，并将临床发现与公认的海马亚区组织原则进行比对。通过对所... more
该文章介绍了 precise and accurate Identification Of Native proteoforms (precisION)，这是一款开源软件工具包，旨在克服 天然自上而下质谱（nTDMS） 在识别和量化复杂蛋白质复合物中隐藏的蛋白质修饰方面的挑战。通过利用稳健的、数据驱动的 片段级开放搜索 和 机器学习算法 来过滤噪声，precisION 能够检测到现有方法难以发现的 低丰度或未表征的翻译后修饰（PTMs）。作者们通过应用 precisION 分析了四种具有治疗意义... more
该研究介绍了一个名为 InterPLM 的系统框架，它利用稀疏自编码器（SAE）从蛋白质语言模型（PLM），特别是 ESM-2 中，提取并分析可解释的特征。作者发现，这些 SAE 特征能够识别出包括结合位点和结构基序在内的数千个生物学概念，这表明 PLM 将概念以叠加的方式存储在神经元中。通过将这些特征与已知生物注释进行对比，该研究证明了 SAE 特征在概念捕获方面的表现远优于原始神经元，并且随着模型规模的扩大，它们能捕获更丰富的生物学知识。此外，该工作还展示了利用大语言模型 (LLM) 自动描... more
该文章介绍了一种用于活细胞中敏感、同步成像不同单信使RNA（mRNA）的新型工具，即RNA稳定的外壳蛋白（RNA-stabilized coat proteins）。研究人员通过蛋白质工程，设计出了条件稳定的dMCP（去稳定化的MS2外壳蛋白）和dPCP（去稳定化的PP7外壳蛋白）变体，它们在未结合RNA时会被细胞快速降解，从而显著降低了背景荧光。这些探针能够高对比度地观察单个mRNA分子，并实现了双色成像，从而能同时追踪细胞内两种不同的RNA种类，这对于研究mRNA的定位和调控至关重要。
R... more
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- AI生成播客
选题挺好，真人聊就好了
Apple Podcasts1Yuantai Sun
China2 months ago
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Apple Podcasts | #23 | China/Science |
Apple Podcasts | #156 |  Taiwan/Science |
Apple Podcasts | #211 |  Netherlands/Science |
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