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JACC Author Interviews

American College of Cardiology
Adult Congenital Heart Disease
Heart Failure
Cardiovascular Disease
Hypertension
Artificial Intelligence
Valvular Heart Disease
Obesity
Health Equity
Pulmonary Arterial Hypertension
Drug-Coated Balloon Angioplasty
Bifurcation Lesions
Natriuretic Peptide Receptor 1 (NPR1)
Hypertrophic Cardiomyopathy
Midventricular Obstruction
Sudden Cardiac Death
Social Determinants Of Health
Underrepresentation Of Africa In Randomized Clinical Trials
Cardiometabolic Trials
Interleukin-6
Drug-Eluting Stents

Interviews with top cardiologists and cardiovascular researchers about breakthrough research, clinical trials, and emerging innovations featured in JACC.

PublishesWeeklyEpisodes54Founded3 months ago
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Artwork for JACC Author Interviews

Latest Episodes

How much of the coronary calcium seen on CT is real, and how much is image artifact? In this episode of Behind the Science, Adith Arun sits down with Dr. Doosup Shin to discuss their JACC study, "Photon-Counting Detector CT Reduces Calcium Overestima... more

How much cardiovascular risk is hidden in the scans we already perform every day? In this episode of Behind the Science, we explore groundbreaking research on imaging-derived sarcopenic obesity and its relationship to heart failure, cardiovascular de... more

In this episode of Behind the Science, Dr. Yogesh Reddy joins to explore how sotatercept improves outcomes in pulmonary arterial hypertension (PAH) and why its effects go beyond traditional vasodilation. Using detailed invasive hemodynamic testing, e... more

In this episode of Behind the Science, we sit down with Dr Yao to discuss the recent JACC publication, "The Prognostic Value of Serum Interleukin-6 Concentrations for 9 Cardiovascular and Mortality Outcomes: The Cross Cohort Collaboration (CCC)." The... more

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Recent Guests

Antoinette Nélong
MD, Institut Cardiovascular Paris-Sud, France
Institut Cardiovascular Paris-Sud, France
Episode: DCB vs DES in Noncomplex Coronary Bifurcation Lesions: REC CAGEFREE I | JACC: Cardiovascular Interventions
Chao Gao
Dr. Gao, from the First Affiliated Hospital of USTC, Hefei, China
First Affiliated Hospital of USTC
Episode: Side Branch Treatment for Bifurcation Revascularization: KISS Trial | JACC: Cardiovascular Interventions
William White
Researcher
Episode: Behind the Science: NPR-1 Agonist for Resistant Hypertension | JACC Author Interviews
Wayne Batchelor
Lead author of Automated Alerts to Improve Timely Evaluation and Treatment of Valvular Heart Disease, The ALERT Trial
Episode: Automated Alerts for Valvular Heart Disease: Insights From the ALERT Trial | ACC.26 | JACC
Helle Søholm
Interventional cardiologist
Copenhagen University Hospital
Episode: Tocilizumab and Low-dose Dobutamine in Acute MI | JACC Author Interviews
Martin Frydland
Heart failure doctor
Copenhagen University Hospital
Episode: Tocilizumab and Low-dose Dobutamine in Acute MI | JACC Author Interviews
Bamba Gaye
Executive director of the Alliance for Medical Research in Africa; adjunct professor
Alliance for Medical Research in Africa; Emory University
Episode: Underrepresentation of Africa in RCTs | JACC Author Interviews
Dr. Naveed Sattar
Professor of Cardiometabolic Medicine at the University of Glasgow
University of Glasgow
Episode: Designing Next-Gen Cardiometabolic Outcome Trials | JACC
Rishi Shah
Co-led five of the JACC data reports in the week's issue
JACC
Episode: Behind the Science: JACC Data Reports | JACC

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Talking Points

Recent interactions between the hosts and their guests.

Behind the Science: What Muscle Health Reveals About Heart Failure Risk | JACC
Q: So where do you see this being used as a tool for intervention in terms of precision cardiology, and how might it interact with therapies like GLP-1s or sarcopenia-targeted interventions?
This could become a tool to tailor interventions by identifying patients who would benefit most from muscle-preserving or muscle-building strategies, including resistance training and metabolic therapies, and to monitor response to such interventions alongside pharmacologic treatments.
Behind the Science: What Muscle Health Reveals About Heart Failure Risk | JACC
Q: And then you maybe could talk a little bit about extending that to the lower risk population, traditionally considered lower risk, and whether you think your measure might hold in that group.
While the UK Biobank population is relatively healthier, the findings suggest that the sarcopenic obesity index can still discriminate risk in a broader population, with potential to refine risk even among those considered lower risk, though further validation in diverse clinical cohorts is needed.
Behind the Science: What Muscle Health Reveals About Heart Failure Risk | JACC
Q: So there's so much that I want to dive into, but maybe I'll start with the question of you guys chose to base the measure off of the pectoralis major muscle mass. And maybe you can talk a little bit about why that choice was made.
The pectoralis major was chosen largely for pragmatic reasons: it is easy to obtain from routine cardiac imaging, aligns with existing workflow, and showed strong concordance with other muscle mass measures, making it a feasible surrogate in everyday practice.
Behind the Science: Central, Hematological and Peripheral Effects of Sotatercept | JACC
Q: What do these findings imply for PAH patients with left-sided heart disease or group 2 PAH, and what's next for cetatercept research?
The data hint at a potential decongestive effect and a remodeling-related axis that could benefit group 2 PAH, though the physiology differs from group 1. Ongoing and planned trials in HEP-PEPH and further mechanistic studies in PAH are needed to confirm applicability and optimize patient selection.
Behind the Science: Central, Hematological and Peripheral Effects of Sotatercept | JACC
Q: You mentioned a potential skeletal muscle and hematologic contribution to the benefits. Can you expand on that?
Beyond pulmonary vascular changes, there was evidence of increased hemoglobin and improved leg-specific AVO2 difference, along with better single-leg exercise performance, suggesting enhanced oxygen extraction and possible skeletal muscle adaptations that contribute to the improvements in overall exercise capacity.

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Frequently Asked Questions About JACC Author Interviews

What is JACC Author Interviews about and what kind of topics does it cover?

The episodes center on cutting-edge cardiovascular research, with deep dives into clinical trial design, risk assessment, and real-world implications for patient care. Topics span risk prediction using biomarkers and imaging, health equity in cardiovascular outcomes, bifurcation and device trials, AI-augmented adjudication in trials, and strategies to translate trial findings into practice. Several conversations emphasize practical takeaways for clinicians and researchers, including trial methodologies, interpretation of complex results, and the impact of structural factors like access to care and representation in trials. A notable strength is the mix of methodological rigor (trial design, endpoints, and analytics) with broad, system-level... more

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Which podcasts are similar to JACC Author Interviews?

These podcasts share a similar audience with JACC Author Interviews:

1. This Week in Cardiology
2. NEJM This Week

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JACC Author Interviews launched 3 months ago and published 54 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on JACC Author Interviews?

Recent guests on JACC Author Interviews include:

1. Antoinette Nélong
2. Chao Gao
3. William White
4. Wayne Batchelor
5. Helle Søholm
6. Martin Frydland
7. Bamba Gaye
8. Dr. Naveed Sattar

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