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Artwork for Chromatography Life

Chromatography Life

Waters Corporation
Chromatography
Glp-1 Peptide Drugs
Method Development
Size-Exclusion Chromatography
Multi-Angle Light Scattering
Dissolution Testing
Aqbd
Separation Science
Chromatographic Methods
Automation
Adeno-Associated Viruses
Data Integrity
Equilibration Injections
Slalom Chromatography
Food Safety
Patient Safety
Calibration Techniques
Empower
Method Validation Manager
Gilead Sciences

Welcome to Chromatography Life, a podcast presented by Waters Corporation. Join us as we dive into the world of chromatography with leading scientists to examine today’s critical challenges. As a hub for the chromatography community, we share the lived experiences, passions, and visions of these scientific innovators as they shape the future of analytical chemistry. Hear from experts across a wide... more

PublishesMonthlyEpisodes11Foundeda year ago
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ChemistryScience

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Artwork for Chromatography Life

Latest Episodes

In our latest episode of Chromatography Life podcast, we explore a fascinating and nearly forgotten separation technique—slalom chromatography—with Dr. Fabrice Gritti, Consulting Scientist at Waters Corporation. Dr. Gritti brings decades of expertise... more

In Episode 9 of Chromatography Life, we sit down with Richard Verseput, a pioneer in QbD-driven analytical development, to explore how automation, risk assessment, and smart experimental design are revolutionizing chromatography. From cutting-edge to... more

Join host Neil Lander as he sits down with Peter Baker, President of Live Oak Quality Assurance and former FDA Investigator of the Year, to explore the complexities of equilibration injections in regulated laboratories. Peter shares his global regula... more

Join host Neil Lander as he sits down with Margaret Maziarz, Principal Scientist at Waters Corporation, to discuss the latest tools and strategic approaches to optimizing method development. Margaret guides us through the advantages to various types ... more

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Recent Guests

Dr. Fabrice Gritti
A consulting scientist at Waters Corporation with extensive experience in chromatography and separation science.
Waters Corporation
Episode: Rediscovering Slalom Chromatography – A Forgotten Technique Reimagined
Richard Verseput
President of S-Matrix Corporation with extensive experience in QbD methodology.
S-Matrix Corporation
Episode: Adopting AQbD Principles to Method Development
Margaret Maziarz
A scientist based in corporate headquarters, responsible for the development of new applications and technical presentations.
Waters Corporation
Episode: Tools to Support Enhanced Method Development
Matt Lauber
Senior Director at Waters, overseeing development and support of columns, reagents, and enzymes for biomolecule analysis.
Waters Corporation
Episode: Advancements and Challenges in GLP-1 Peptide Drugs
Arnaud Delobel
R&D and Innovation Director at Quality Assistance, expert in analytical sciences with a focus on biotherapeutics.
Quality Assistance
Episode: Challenges of Chromatographic Analysis for New Modalities
Waters Corporation
A leading analytical instrument manufacturer known for its innovations in chromatography and mass spectrometry.
Waters Corporation
Episode: Challenges of Chromatographic Analysis for New Modalities
Ben Calvopina
Application scientist and product leader for Dissolution at Sotax.
Sotax
Episode: Automating Dissolution in the Laboratory
Tom Walter
Corporate fellow in the consumables and lab automation division at Waters Corporation
Waters Corporation
Episode: The Evolution of UPLC Columns
Katy Rhynard
Associate Director of Laboratory Sciences at Gilead Sciences, leading a team of 20 people managing chromatography systems
Gilead Sciences
Episode: Validating Chromatographic Methods: Challenges, Tools, and Optimization

Host

Neil Lander
Host of Chromatography Life, with a background in analytical chemistry and a strong focus on chromatography innovations.

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Rediscovering Slalom Chromatography – A Forgotten Technique Reimagined
Q: How does slalom chromatography help identify impurities in RNA, which are used for making mRNA therapeutics?
Slalom chromatography effectively separates different RNA species based on their size and conformation, enabling the identification of impurities in therapeutic preparations.
Rediscovering Slalom Chromatography – A Forgotten Technique Reimagined
Q: So what are the limitations of other techniques used to analyze DNA and RNA? And what benefits does slalom chromatography have over those techniques?
Traditional methods like ELISA lack resolution and repeatability, while slalom chromatography provides clear peak distinctions and higher sensitivity.
Rediscovering Slalom Chromatography – A Forgotten Technique Reimagined
Q: Can you tell us about why historically a separation mode is called slalom chromatography?
Historically, slalom chromatography was discovered when scientists observed an unexpected separation of large DNA strands that opposed conventional expectations.
Equilibration Injections Under the Microscope
Q: Is there a way to provide the regulator assurance that no sample injections are performed during the equilibration process?
Yes, by using clearly distinguishable standards, such as degradation or diluted standards instead of actual samples, and ensuring proper SOPs are followed, laboratories can provide assurance to regulators.
Equilibration Injections Under the Microscope
Q: How do the regulators view equilibration injections that are performed prior to the start of a GXP sample queue?
Regulators can find equilibration injections unsettling, particularly if there is a lack of clear oversight and protocols established in the laboratory. They view these injections critically as potential areas of concern regarding data integrity and patient safety.

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Frequently Asked Questions About Chromatography Life

What is Chromatography Life about and what kind of topics does it cover?

Focused on chromatography, this series serves as a platform for scientific discussion, tackling key challenges within analytical chemistry and laboratory practices. Various episodes feature insights from experienced scientists on topics including automated quality design principles, chromatography methods, regulatory implications, and innovative laboratory technologies. Noteworthy is the emphasis on collaboration and community, providing a shared space for professionals to discuss advancements and problems in their fields, from food safety to patient safety and environmental concerns. This podcast appeals to those looking to deepen their understanding of chromatography and its critical applications across numerous industries.

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Which podcasts are similar to Chromatography Life?

These podcasts share a similar audience with Chromatography Life:

1. ゆるコンピュータ科学ラジオ
2. Science Quickly
3. ゆる言語学ラジオ
4. The Daily
5. Freakonomics Radio

How many episodes of Chromatography Life are there?

Chromatography Life launched a year ago and published 11 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on Chromatography Life?

Recent guests on Chromatography Life include:

1. Dr. Fabrice Gritti
2. Richard Verseput
3. Margaret Maziarz
4. Matt Lauber
5. Arnaud Delobel
6. Waters Corporation
7. Ben Calvopina
8. Tom Walter

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