Rephonic
Artwork for Breakpoints
Antimicrobial Stewardship
Infectious Diseases
Antimicrobial Resistance
Rifampin
Antibiotic Resistance
Microbiome
Daptomycin
Staphylococcus Aureus
Tetracyclines
Vancomycin
Intraamniotic Infections
Antibiotic Stewardship
Surgical Site Infections
EHR Optimization
Catheter-Related Bloodstream Infections
Cytomegalovirus
Biofilms
Periprosthetic Joint Infections
Community-Acquired Pneumonia
Metallo-Beta-Lactamases

The SIDP Podcast

PublishesTwice monthlyEpisodes138Founded7 years ago
Number of ListenersCategories
Health & FitnessEducation

Listen to this Podcast

Artwork for Breakpoints

Latest Episodes

In this must-listen episode, Dr. Ryan Moenster is joined by Dr. Monica Mahoney and Dr. Mark Gilchrist to dive deep into the evolving landscape of outpatient parenteral antimicrobial therapy (OPAT) and complex outpatient antimicrobial therapy (CoPAT),... more

In this must-listen episode, Dr. Ryan Moenster and Dr. Megan Klatt dive deep into the latest infectious diseases trials, guidelines, and novel therapeutics. Staying current in the field is a challenge, but this podcast episode does the legwork for yo... more

Group A Streptococcal infections remain a global challenge, spanning common conditions like pharyngitis to severe invasive disease. Dr. Shiranee Sriskandan, Dr. Josh Osowicki, and Dr. Tom Parks join host Dr. Erin McCreary to explore the evolving land... more

Small hospitals bring unique stewardship challenges, but also unique opportunities. Dr. Tina Khadem and Dr. Ashley Cubillos join host Dr. Whitney Buckel to discuss the realities of antimicrobial stewardship in small and critical access hospitals. Fro... more

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Recent Guests

Josh Osowicki
Pediatric infectious diseases physician; vaccine research focus
Murdoch Children's Research Institute, Melbourne
Episode: #136 – GAS, Streptococcus pyogenes: Call It What You Want, It’s Got a Big Reputation
Shiranee Sriskandan
Clinical Professor of Infectious Diseases
Imperial College London
Episode: #136 – GAS, Streptococcus pyogenes: Call It What You Want, It’s Got a Big Reputation
Tom Parks
Clinical Associate Professor in Infectious Diseases
Imperial College London
Episode: #136 – GAS, Streptococcus pyogenes: Call It What You Want, It’s Got a Big Reputation
Ashley Cubillos
Antimicrobial Stewardship and Infectious Diseases Pharmacy Clinical Specialist for five Banner Health acute care facilities
Banner Health
Episode: #135 – Stewie Struggles: Small Hospital Edition
Tina Khadem
Infectious Diseases and Stewardship Pharmacist and System Antimicrobial Stewardship Program Director
UPMC
Episode: #135 – Stewie Struggles: Small Hospital Edition
Mical Paul
Professor in the research track at Technion – Israel Institute of Technology; head of Infectious Diseases Institute at Rambam Health Care Campus; ESCMID Guidelines Methodologist
Technion / Rambam Health Care Campus / ESCMID
Episode: #134 – ESCMID Global Trials: PETER PEN and ASTARTE
Jesús Rodríguez-Baño
Professor of Medicine, University of Sevilla; Head of Infectious Diseases Department, Hospital Universitario Macarena; former ESCMID President; CMI Editor-in-Chief
University of Sevilla / Hospital Universitario Macarena / CMI
Episode: #134 – ESCMID Global Trials: PETER PEN and ASTARTE
Shreya Doshi
Attending physician, pediatric infectious diseases; co-founder of Sustainability
Children's National Hospital; George Washington University
Episode: #133 – Trash talk: Earth Day Special on Healthcare Sustainability and Stewardship
Preeti Jaggi
Professor of pediatrics; medical director of antimicrobial stewardship
Emory University; Children's Healthcare of Atlanta
Episode: #133 – Trash talk: Earth Day Special on Healthcare Sustainability and Stewardship

Hosts

Whitney Buckel
Host of Breakpoints
Erin McCreary
Co-host of Breakpoints; Infectious Diseases leadership and strategy advocate

Reviews

4.9 out of 5 stars from 284 ratings
  • A wonderful ID Podcast

    Breakpoints can always be counted on for an insightful perspective on ID issues.

    Apple Podcasts
    5
    DSueMZ
    United Statesa month ago
  • Excellent

    I love this podcast. I work in ID and find this so on point!

    Apple Podcasts
    5
    Jjunie2016
    United States2 months ago
  • Pharmacist recommended!

    By far one of the most informative and worthwhile podcasts for every pharmacist (and also other healthcare professionals) to give a listen to. I love the reviews of current best practices mixed with new and upcoming evidence based practices.

    Apple Podcasts
    5
    Hanimmal
    United States5 months ago
  • More dosing consults :)

    I love the dosing consults with practical points for the every day clinician! Especially on our older drugs that we use every day.

    Apple Podcasts
    5
    srlinford
    United States2 years ago
  • Breakpoints for the win!

    This podcasts never disappoints. Love hearing perspectives of top infectious disease clinicians and pharmacists!

    Apple Podcasts
    5
    Cap429
    United States3 years ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Evidence-based and conversational, great for daily practice.
Informative and practical for pharmacists and clinicians.
The show offers insightful perspectives on ID issues.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Apple Podcasts
#227
Argentina/Health & Fitness
Apple Podcasts
#238
Singapore/Health & Fitness
Apple Podcasts
#248
Belgium/Health & Fitness

Talking Points

Recent interactions between the hosts and their guests.

#136 – GAS, Streptococcus pyogenes: Call It What You Want, It’s Got a Big Reputation
Q: What is STRAP and what questions does it aim to answer?
STRAP is a Streptococcal Adaptive Platform Trial designed to evaluate definitive therapies for invasive GAS disease across domains (backbone antibiotics, adjunctive antibiotics like clindamycin or linezolid, and IVIG for severe cases) with a mortality and day-30 alive outcome to determine optimal treatment regimens.
#136 – GAS, Streptococcus pyogenes: Call It What You Want, It’s Got a Big Reputation
Q: Why has developing a vaccine for Group A Streptococcus been so challenging?
The organism lacks a capsule, has a hyaluronan capsule that defeats simple capsule-based vaccines, expresses multiple virulence factors, and over 100 M types mean a single-target vaccine would be insufficient; thus, multi-antigen strategies and consideration of surface proteins like M proteins are being explored, with safety concerns about autoimmunity historically limiting progress.
#134 – ESCMID Global Trials: PETER PEN and ASTARTE
Q: What about the interim analysis and the decision to continue or stop?
The Marino trial backdrop and a pre-specified stopping rule meant the Peter Pen team faced a decision point about continuing after interim signals; the discussions emphasized that stopping early can inflate apparent effects, and the team chose to continue to validate non-inferiority with accumulating data.
#134 – ESCMID Global Trials: PETER PEN and ASTARTE
Q: Could you walk through the power calculation and how many patients were needed versus what was recruited?
Power calculations used a non-inferiority framework with different assumptions for mortality and failure, leading to an estimated 500 patients for the primary outcome; recruitment progressed slowly across eight centers, and eventual interim analyses influenced decisions about continuing the trial.
#134 – ESCMID Global Trials: PETER PEN and ASTARTE
Q: With Peter Pen, can you describe the trial setting, eligibility criteria, and the primary outcome?
The Peter Pen trial was investigator-initiated, enrolling patients with bloodstream infections due to ESBL producers, excluding those with penicillin allergies or requiring additional antibiotics; the primary outcome mirrored the Marino trial focusing on 30-day mortality, with a composite primary outcome including clinical failure at day seven to address a smaller, more actionable endpoint.

Audience Metrics

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Frequently Asked Questions About Breakpoints

What is Breakpoints about and what kind of topics does it cover?

The show centers on infectious diseases pharmacotherapy, antimicrobial stewardship, and practical clinical guidance for real-world settings. Across episodes, discussions span small and large hospital stewardship, guideline development and implementation, pediatric dosing, environmental sustainability in healthcare, and the evolving landscape of new therapies and diagnostics. Noteworthy are deep-dive trials, global guideline debates, and pragmatic strategies that bridge evidence with local context, often featuring leading pharmacists, physicians, and researchers. The format tends to blend technical detail with accessible, conversational banter, making complex topics approachable for clinicians seeking actionable takeaways.

Potential listene... more

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Which podcasts are similar to Breakpoints?

These podcasts share a similar audience with Breakpoints:

1. Infectious Disease Puscast
2. Febrile
3. Communicable
4. ID:IOTS - Infectious Disease Insight Of Two Specialists
5. The Curious Clinicians

How many episodes of Breakpoints are there?

Breakpoints launched 7 years ago and published 138 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on Breakpoints?

Recent guests on Breakpoints include:

1. Josh Osowicki
2. Shiranee Sriskandan
3. Tom Parks
4. Ashley Cubillos
5. Tina Khadem
6. Mical Paul
7. Jesús Rodríguez-Baño
8. Shreya Doshi

To view more recent guests and their details, simply upgrade your Rephonic account. You'll also get access to a typical guest profile to help you decide if the show is worth pitching.

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