Breakpoints

Society of Infectious Diseases Pharmacists

Antimicrobial Stewardship

Infectious Diseases

Antimicrobial Resistance

Rifampin

Antibiotic Resistance

Microbiome

Daptomycin

Staphylococcus Aureus

Tetracyclines

Vancomycin

Intraamniotic Infections

Antibiotic Stewardship

EHR Optimization

Cytomegalovirus

Surgical Site Infections

Biofilms

Periprosthetic Joint Infections

Catheter-Related Bloodstream Infections

Community-Acquired Pneumonia

Metallo-Beta-Lactamases

The SIDP Podcast

288 ratings

Publishes	Twice monthly	Episodes	141	Founded	7 years ago
Number of Listeners		Categories	Health & FitnessEducation

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Latest Episodes

#141 – Prostatitis: Hard to Reach, Harder to Treat

Dr. Prathit Kulkarni, lead author of a recent state-of-the-art review on acute and chronic bacterial prostatitis, joins host Dr. Erin McCreary to discuss this complex disease state. They walk through diagnosis, epidemiology, treatment, and more. You ... more

Today • 58 min

#140 – Beta-lactamase inhibitors: “Scientifically elegant, just complex"

Gram-negative resistance is beautifully intricate, scientifically elegant, and very complex. Nothing is more exciting than the recently approved and bursting pipeline of beta-lactamase inhibitors. Listen to Drs. Sam Aitken and Christophe Le Terrier, ... more

21 Aug 2026 • 1 hr 16 min • Most popular

#139 – The ART of HIV Care: Evidence, Pearls and Practice

Join Dr. Whitney Buckel and leading HIV experts Dr. William Short and Dr. Ryan Tomlin for an engaging discussion on the current and future state of HIV care. As treatment and prevention options continue to evolve, clinicians face new opportunities an... more

31 Jul 2026 • 1 hr 9 min

#138 – You CAN Go Home Again: A review of OPAT and CoPAT from the MAD-ID/SIDP Annual Meeting

In this must-listen episode, Dr. Ryan Moenster is joined by Dr. Monica Mahoney and Dr. Mark Gilchrist to dive deep into the evolving landscape of outpatient parenteral antimicrobial therapy (OPAT) and complex outpatient antimicrobial therapy (CoPAT),... more

3 Jul 2026 • 1 hr 14 min

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Recent Guests

Sam Aitken

infectious diseases pharmacist; former SIDP president

University of Michigan

Episode: #140 – Beta-lactamase inhibitors: “Scientifically elegant, just complex"

Christophe Le Terrier

MD PhD; intensivist and antimicrobial resistance researcher

University Hospitals of Geneva; University of Freiburg

Episode: #140 – Beta-lactamase inhibitors: “Scientifically elegant, just complex"

Bill Short

Associate Professor of Medicine, Infectious Diseases

Perelman School of Medicine

Episode: #139 – The ART of HIV Care: Evidence, Pearls and Practice

Ryan Tomlin

Clinical Pharmacist specializing in HIV medicine

Trinity Health Grand Rapids McCauley Clinic

Episode: #139 – The ART of HIV Care: Evidence, Pearls and Practice

Monica Mahoney

ID pharmacist at Beth Israel Deaconess Medical Center, OPAT program lead

Beth Israel Deaconess Medical Center

Episode: #138 – You CAN Go Home Again: A review of OPAT and CoPAT from the MAD-ID/SIDP Annual Meeting

Mark Gilchrist

Consultant Pharmacist, ID and Head of Antimicrobial Stewardship at Imperial College Health Care NHS Trust

Imperial College Health Care NHS Trust

Episode: #138 – You CAN Go Home Again: A review of OPAT and CoPAT from the MAD-ID/SIDP Annual Meeting

Josh Osowicki

Pediatric infectious diseases physician; vaccine research focus

Murdoch Children's Research Institute, Melbourne

Episode: #136 – GAS, Streptococcus pyogenes: Call It What You Want, It’s Got a Big Reputation

Shiranee Sriskandan

Clinical Professor of Infectious Diseases

Imperial College London

Episode: #136 – GAS, Streptococcus pyogenes: Call It What You Want, It’s Got a Big Reputation

Tom Parks

Clinical Associate Professor in Infectious Diseases

Imperial College London

Episode: #136 – GAS, Streptococcus pyogenes: Call It What You Want, It’s Got a Big Reputation

Hosts

Whitney Buckel

Host of Breakpoints with ties to infectious diseases pharmacology and SIDP leadership.

Ryan Moenster

Co-host presenting, delivering content; professor of Pharmacy Practice with ID stewardship focus.

Erin McCreary

Host of Breakpoints; ID clinician and pharmacist with leadership in ID strategy.

Reviews

4.9 out of 5 stars from 288 ratings

A wonderful ID Podcast
Breakpoints can always be counted on for an insightful perspective on ID issues.
Apple Podcasts
5
DSueMZ
United States3 months ago
Excellent
I love this podcast. I work in ID and find this so on point!
Apple Podcasts
5
Jjunie2016
United States4 months ago
Pharmacist recommended!
By far one of the most informative and worthwhile podcasts for every pharmacist (and also other healthcare professionals) to give a listen to. I love the reviews of current best practices mixed with new and upcoming evidence based practices.
Apple Podcasts
5
Hanimmal
United States7 months ago
More dosing consults :)
I love the dosing consults with practical points for the every day clinician! Especially on our older drugs that we use every day.
Apple Podcasts
5
srlinford
United States2 years ago
Breakpoints for the win!
This podcasts never disappoints. Love hearing perspectives of top infectious disease clinicians and pharmacists!
Apple Podcasts
5
Cap429
United States3 years ago

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Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Listeners praise practical, evidence-based discussions and actionable takeaways for daily practice.

The show is appreciated for being accessible to a broad healthcare audience beyond ID specialists.

Guests and hosts are described as top experts delivering clear, engaging conversations.

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Talking Points

Recent interactions between the hosts and their guests.

#136 – GAS, Streptococcus pyogenes: Call It What You Want, It’s Got a Big Reputation

Q: What is STRAP and what questions does it aim to answer?

STRAP is a Streptococcal Adaptive Platform Trial designed to evaluate definitive therapies for invasive GAS disease across domains (backbone antibiotics, adjunctive antibiotics like clindamycin or linezolid, and IVIG for severe cases) with a mortality and day-30 alive outcome to determine optimal treatment regimens.

#136 – GAS, Streptococcus pyogenes: Call It What You Want, It’s Got a Big Reputation

Q: Why has developing a vaccine for Group A Streptococcus been so challenging?

The organism lacks a capsule, has a hyaluronan capsule that defeats simple capsule-based vaccines, expresses multiple virulence factors, and over 100 M types mean a single-target vaccine would be insufficient; thus, multi-antigen strategies and consideration of surface proteins like M proteins are being explored, with safety concerns about autoimmunity historically limiting progress.

#134 – ESCMID Global Trials: PETER PEN and ASTARTE

Q: What about the interim analysis and the decision to continue or stop?

The Marino trial backdrop and a pre-specified stopping rule meant the Peter Pen team faced a decision point about continuing after interim signals; the discussions emphasized that stopping early can inflate apparent effects, and the team chose to continue to validate non-inferiority with accumulating data.

#134 – ESCMID Global Trials: PETER PEN and ASTARTE

Q: Could you walk through the power calculation and how many patients were needed versus what was recruited?

Power calculations used a non-inferiority framework with different assumptions for mortality and failure, leading to an estimated 500 patients for the primary outcome; recruitment progressed slowly across eight centers, and eventual interim analyses influenced decisions about continuing the trial.

#134 – ESCMID Global Trials: PETER PEN and ASTARTE

Q: With Peter Pen, can you describe the trial setting, eligibility criteria, and the primary outcome?

The Peter Pen trial was investigator-initiated, enrolling patients with bloodstream infections due to ESBL producers, excluding those with penicillin allergies or requiring additional antibiotics; the primary outcome mirrored the Marino trial focusing on 30-day mortality, with a composite primary outcome including clinical failure at day seven to address a smaller, more actionable endpoint.

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Frequently Asked Questions About Breakpoints

What is Breakpoints about and what kind of topics does it cover?

The show centers on infectious diseases, antimicrobial stewardship, and clinical pharmacotherapy, with a strong emphasis on practical, evidence-based guidance for frontline clinicians. Episodes frequently feature expert panels of infectious diseases physicians, pharmacists, and researchers who discuss guideline updates, case-based management, emerging therapies, and health-system implementation challenges. A notable strength is the mix of clinical deep-dives, real-world program experiences, and discussions of stewardship, with conversations that are accessible to practitioners while remaining technically rigorous. The format often blends practical dosing, policy and payer implications, and innovative approaches to patient care in diverse he... more

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Which podcasts are similar to Breakpoints?

These podcasts share a similar audience with Breakpoints:

1. Infectious Disease Puscast
2. Communicable
3. ID:IOTS - Infectious Disease Insight Of Two Specialists
4. Core IM | Internal Medicine Podcast
5. Annals On Call Podcast

How many episodes of Breakpoints are there?

Breakpoints launched 7 years ago and published 141 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on Breakpoints?

Recent guests on Breakpoints include:

1. Sam Aitken
2. Christophe Le Terrier
3. Bill Short
4. Ryan Tomlin
5. Monica Mahoney
6. Mark Gilchrist
7. Josh Osowicki
8. Shiranee Sriskandan

To view more recent guests and their details, simply upgrade your Rephonic account. You'll also get access to a typical guest profile to help you decide if the show is worth pitching.

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