
Between Two COOs is hosted by veteran COO Michael Koenig and brings together Chief Operating Officers, executives, and business leaders to share real insights on operations, leadership, scaling, AI, and execution. Featuring COOs from companies like LVMH, Vodafone, Automattic, Lime, JumpCloud, Grafana Labs, and Cotopaxi, plus top VCs like Brad Feld and Seth Levine. Whether you're a COO, VP of Ops, ... more
| Publishes | Weekly | Episodes | 70 | Founded | 5 years ago |
|---|---|---|---|---|---|
| Number of Listeners | Categories | ManagementBusinessEntrepreneurship | |||

Tom Masterson, COO of Deep Genomics, on AI drug discovery where precision beats creativity. He explains how the company's siRNA model picked an approved cholesterol drug out of 3,500 candidates for a target it had never seen, why it designs toxic mol... more
Paul Kedrosky of SK Ventures says AI capex is driving up to 70 percent of US GDP growth, and most of it is now borrowed. He walks through the money map, the 2029 maturity wall, why AI tokens are a deflationary commodity, and three ways the AI bubble ... more
Lior Eldan, co-founder and COO of Moburst, has reinvented what his agency sells three times, from app store optimization to AI products. He explains why replacing people with AI is backwards, why managers have to do the work, and why automating a bro... more
Part 2 of 2. Part 1 is here: betweentwocoos.com/65
In part 1, Joe Yaffe explained how an orbital data center works. This time, the question is
whether it works as a business.
In this episode, Joe and Michael discuss:
• Why Cowboy Space ... more
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Hearing Michael interview other COOs will give you the impression that the job is mostly for those serendipitous types who are as comfortable accepting responsibility for accidental success as they are nonchalant about climbing Mount Everest.
Ok you caught me, I’m a friend of Micheal (at least until he reads this review) so I’m biased. But I listen because as an entrepreneur the stories and lessons have helped me steer my own business better than I could have done by ignoring them.
Michael, wh... more
Thanks for taking the time to produce such a high quality podcast. As a new COO I’ve already taken away some gems from your conversations. I look forward to all the upcoming episodes.
Best resource out there for COOs! My new FAVORITE podcast.
Very interesting and informative discussion about being a COO by two COOs. Worth the time spent listening. Very relatable.
Key themes from listener reviews, highlighting what works and what could be improved about the show.
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Apple Podcasts | #118 | |
Apple Podcasts | #206 |
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This show concentrates on operations, leadership, and execution at scale, with frequent deep dives into how COOs and senior operators drive process, strategy, and AI adoption across diverse industries. Guests range from climate-tech and space-enabled compute ventures to payments, identity, and enterprise SaaS, offering practical frameworks, governance practices, and lessons learned from building durable, growth-focused organizations. A standout throughline is the emphasis on sustainable operating systems, cross-functional collaboration, and the human side of leadership in fast-moving tech environments, making it valuable for current and aspiring operators looking for actionable, battle-tested insights.
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1. The Dick & Paul Show
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3. The Peter Zeihan Podcast Series
4. Cheeky Pint
5. Better Offline
Between Two COO's launched 5 years ago and published 70 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.
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Recent guests on Between Two COO's include:
1. Tom Masterson
2. Paul Kedrosky
3. Lior Eldan
4. Joe Yaffe
5. Riikka Söderlund
6. Wade Foster
7. Zulema Quintans
8. Peter Rojas
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