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Better Biopharma

Tyler Menichiello
Biopharmaceuticals
Biomanufacturing
Car T Therapy
Alzheimer's Disease
Clinical Trials
Drug Development
FDA
Process Development
Therapies
Antibody Drug Development
Biotechnology
C Difficile Infection
Lumen Biosciences
G Protein-Coupled Receptors
Functional Antibody Screening
Johnson & Johnson
Neuroinflammation
Conditionally Active Biologics
Oral Vaccines
Artificial Intelligence

“How can biopharma improve?” This question is the guiding ethos of the Better Biopharma podcast. Through conversations with experts across the biopharma landscape, host Tyler Menichiello explores the work being done to make better medicines and optimize manufacturing. Each episode is a dive into the guest's methods, their curiosity, and their determination. By shining a light on the visionaries pu... more

PublishesTwice monthlyEpisodes22Founded9 months ago
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ScienceLife Sciences

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Artwork for Better Biopharma

Latest Episodes

In this episode of “Better Biopharma,” panelists from the Bioprocess Online Live event “Optimizing Process Development Through Upstream And Downstream Integration” continue their conversation about how upstream and downstream development teams can wo... more

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In this episode of “Better Biopharma,” host Tyler Menichiello speaks with Michael McCullar, Ph.D., CEO at RegCell, a cell-therapy company developing regulatory T cell (Treg) therapies for autoimmune diseases. They discuss RegCell’s origins and its di... more

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In this episode of “Better Biopharma,” host Tyler Menichiello is joined by Nikolai Sopko, MD, Ph.D., chief operating officer, chief scientific officer, and director at PolarityBio, a biotech company developing SkinTE, an investigational autologous re... more

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In this episode of “Better Biopharma,” host Tyler Menichiello is joined by Richard Moroney, Ph.D., managing director at Stat Consulting. Moroney shares his thoughts on how organizations should think about and approach process control. His philosophy ... more

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Recent Guests

Michael McCullar
CEO of RegCell
RegCell
Episode: Reprogramming T Cells And Reducing Manufacturing Costs With RegCell’s Michael McCullar, Ph.D.
Nikolai Sopko
Chief Operating Officer, Chief Scientific Officer, and Director at PolarityBio
PolarityBio
Episode: Scaling Regenerative Medicine Production With PolarityBio’s Nikolai Sopko, MD, Ph.D.
Richard Moroney
Managing Director at Stat Consulting
Stat Consulting
Episode: Pursuing Quality While Maintaining Process Control With Richard Moroney, Ph.D.
Pete O'Heeron
CEO of FibroBiologics
FibroBiologics
Episode: Unlocking The Therapeutic Power Of Fibroblasts With Pete O’Heeron And Hamid Khoja, Ph.D.
Hamid Khoja
Chief Scientific Officer of FibroBiologics
FibroBiologics
Episode: Unlocking The Therapeutic Power Of Fibroblasts With Pete O’Heeron And Hamid Khoja, Ph.D.
Eric Doerr
Drug substance technical lead, Manufacturing Sciences, Analytics and Technology group at Sanofi
Sanofi
Episode: Supporting The Bioprocessing Workforce In The AI Era With Sanofi's Eric Doerr
Dr. Tugce Martagan
Professor of industrial engineering at Northeastern University.
Northeastern University
Episode: Combining AI With Operations Research To Advance Biomanufacturing With Tinglong Dai, Ph.D., and Tugce Martagan, Ph.D.
Dr. Tinglong Dai
Professor of business at Johns Hopkins University.
Johns Hopkins University
Episode: Combining AI With Operations Research To Advance Biomanufacturing With Tinglong Dai, Ph.D., and Tugce Martagan, Ph.D.
Sean Tucker
Founder, Senior Vice President, and Chief Scientific Officer of Vaxart.
Vaxart
Episode: Building An Oral Vaccine Platform With Vaxart's Sean Tucker, Ph.D.

Host

Tyler Menichiello
Host exploring the work being done to improve biopharma through conversations with experts.

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Reprogramming T Cells And Reducing Manufacturing Costs With RegCell’s Michael McCullar, Ph.D.
Q: Where do you see point-of-care manufacturing fitting in, and how is RegCell contributing?
Point-of-care production is envisioned through automated, closed systems that can operate in smaller centers, reducing the need for large GMP facilities and improving patient access; analytics and in situ monitoring will further streamline the process.
Reprogramming T Cells And Reducing Manufacturing Costs With RegCell’s Michael McCullar, Ph.D.
Q: What are the hurdles to improving commercial viability, particularly manufacturing cost?
Automation and the exclusion of viral vectors, combined with a lighter materials bill of materials and reduced idle capacity, are central to lowering costs; the aim is to push production closer to patients through scalable, closed systems to reduce labor and facility expenses.
Unlocking The Therapeutic Power Of Fibroblasts With Pete O’Heeron And Hamid Khoja, Ph.D.
Q: What is the regulatory outlook for spheroid-based therapies in the US compared to Australia?
Australia has shown receptivity to the technology in early trials; in the US, the plan is to work closely with the FDA to build INDs, leveraging the evolving regulatory landscape that is adapting to cell-based therapies and regimens beyond traditional small molecules.
Unlocking The Therapeutic Power Of Fibroblasts With Pete O’Heeron And Hamid Khoja, Ph.D.
Q: What are the manufacturing challenges for fibroblast spheroids and how are you addressing them?
The team had to invent bespoke in-house infrastructure, including specialized trays, scalable culture systems, and custom assays to measure identity, potency, and viability in a 3D spheroid format, along with transferring the process to contract manufacturers with careful tech transfer and regulatory alignment.
Unlocking The Therapeutic Power Of Fibroblasts With Pete O’Heeron And Hamid Khoja, Ph.D.
Q: Why have fibroblasts, particularly fibroblasts in spheroid form, emerged as a compelling therapeutic modality?
Fibroblasts are abundant, easier to harvest and scale, and less prone to spontaneous differentiation than stem cells. Spheroids further enhance their immune modulation, prolong target exposure, and reduce innate immune responses, making them more versatile and potentially more effective across multiple indications.

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Frequently Asked Questions About Better Biopharma

What is Better Biopharma about and what kind of topics does it cover?

Centered around the theme of improvement in biopharmaceuticals, content focuses on advancements in manufacturing practices, regulatory challenges, and innovative therapies within the life sciences sector. Each episode features conversations with leading experts who share insights on their strategies, research, and the latest trends impacting drug development and biomanufacturing. The discussions cover a wide array of topics such as gene therapy, vaccine development, regenerative medicine, and AI applications in operations research. This podcast aims to educate and inspire professionals engaged in biopharma, fostering collaboration and innovative thinking to enhance patient outcomes and industry standards.

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Which podcasts are similar to Better Biopharma?

These podcasts share a similar audience with Better Biopharma:

1. The Readout Loud
2. The Mel Robbins Podcast

How many episodes of Better Biopharma are there?

Better Biopharma launched 9 months ago and published 22 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on Better Biopharma?

Recent guests on Better Biopharma include:

1. Michael McCullar
2. Nikolai Sopko
3. Richard Moroney
4. Pete O'Heeron
5. Hamid Khoja
6. Eric Doerr
7. Dr. Tugce Martagan
8. Dr. Tinglong Dai

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