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Better Biopharma

Tyler Menichiello
Biopharmaceuticals
Biomanufacturing
CAR T Therapy
Alzheimer's Disease
Clinical Trials
Drug Development
Therapies
Process Development
Antibody Drug Development
Biotechnology
FDA
C Difficile Infection
Lumen Biosciences
G Protein-Coupled Receptors
Functional Antibody Screening
Johnson & Johnson
Neuroinflammation
Conditionally Active Biologics
Oral Vaccines
Artificial Intelligence

“How can biopharma improve?” This question is the guiding ethos of the Better Biopharma podcast. Through conversations with experts across the biopharma landscape, host Tyler Menichiello explores the work being done to make better medicines and optimize manufacturing. Each episode is a dive into the guest's methods, their curiosity, and their determination. By shining a light on the visionaries pu... more

PublishesTwice monthlyEpisodes19Founded8 months ago
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Life SciencesScience

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Artwork for Better Biopharma

Latest Episodes

In this episode of “Better Biopharma,” host Tyler Menichiello is joined by Richard Moroney, Ph.D., managing director at Stat Consulting. Moroney shares his thoughts on how organizations should think about and approach process control. His philosophy ... more

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In this episode of “Better Biopharma,” host Tyler Menichiello is joined by FibroBiologics’ CEO and founder, Pete O’Heeron, and chief scientific officer, Hamid Khoja, Ph.D. They discuss the powerful but often overlooked fibroblast, a type of connectiv... more

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In this episode of “Better Biopharma,” host Tyler Menichiello is joined by Eric Doerr, a drug substance technical lead in the manufacturing science and technology (MSAT) group at Sanofi. The two discuss how the industry can support the next generatio... more

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In this episode of “Better Biopharma,” host Tyler Menichiello is joined by Herman Bozenhardt, a consultant and industry veteran who has spent decades advancing the fields of biopharmaceutical manufacturing, engineering, and regulatory compliance. Boz... more

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Recent Guests

Richard Moroney
Managing Director at Stat Consulting
Stat Consulting
Episode: Pursuing Quality While Maintaining Process Control With Richard Moroney, Ph.D.
Pete O'Heeron
CEO of FibroBiologics
FibroBiologics
Episode: Unlocking The Therapeutic Power Of Fibroblasts With Pete O’Heeron And Hamid Khoja, Ph.D.
Hamid Khoja
Chief Scientific Officer of FibroBiologics
FibroBiologics
Episode: Unlocking The Therapeutic Power Of Fibroblasts With Pete O’Heeron And Hamid Khoja, Ph.D.
Eric Doerr
Drug substance technical lead, Manufacturing Sciences, Analytics and Technology group at Sanofi
Sanofi
Episode: Supporting The Bioprocessing Workforce In The AI Era With Sanofi's Eric Doerr
Dr. Tugce Martagan
Professor of industrial engineering at Northeastern University.
Northeastern University
Episode: Combining AI With Operations Research To Advance Biomanufacturing With Tinglong Dai, Ph.D., and Tugce Martagan, Ph.D.
Dr. Tinglong Dai
Professor of business at Johns Hopkins University.
Johns Hopkins University
Episode: Combining AI With Operations Research To Advance Biomanufacturing With Tinglong Dai, Ph.D., and Tugce Martagan, Ph.D.
Sean Tucker
Founder, Senior Vice President, and Chief Scientific Officer of Vaxart.
Vaxart
Episode: Building An Oral Vaccine Platform With Vaxart's Sean Tucker, Ph.D.
Patrick Bilbo
Chief Operating Officer at Organogenesis
Organogenesis
Episode: Lessons In Scaling Regenerative Medicine Manufacturing With Organogenesis's Patrick Bilbo
Diane Hollenbaugh, Ph.D.
Chief Scientific Officer at Bonum Therapeutics
Bonum Therapeutics
Episode: Navigating The Complexity of Conditionally Active Biologics With Bonum Therapeutics' Diane Hollenbaugh, Ph.D., and Neela Patel, Ph.D.

Host

Tyler Menichiello
Host exploring the work being done to improve biopharma through conversations with experts.

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Talking Points

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Unlocking The Therapeutic Power Of Fibroblasts With Pete O’Heeron And Hamid Khoja, Ph.D.
Q: What is the regulatory outlook for spheroid-based therapies in the US compared to Australia?
Australia has shown receptivity to the technology in early trials; in the US, the plan is to work closely with the FDA to build INDs, leveraging the evolving regulatory landscape that is adapting to cell-based therapies and regimens beyond traditional small molecules.
Unlocking The Therapeutic Power Of Fibroblasts With Pete O’Heeron And Hamid Khoja, Ph.D.
Q: What are the manufacturing challenges for fibroblast spheroids and how are you addressing them?
The team had to invent bespoke in-house infrastructure, including specialized trays, scalable culture systems, and custom assays to measure identity, potency, and viability in a 3D spheroid format, along with transferring the process to contract manufacturers with careful tech transfer and regulatory alignment.
Unlocking The Therapeutic Power Of Fibroblasts With Pete O’Heeron And Hamid Khoja, Ph.D.
Q: Why have fibroblasts, particularly fibroblasts in spheroid form, emerged as a compelling therapeutic modality?
Fibroblasts are abundant, easier to harvest and scale, and less prone to spontaneous differentiation than stem cells. Spheroids further enhance their immune modulation, prolong target exposure, and reduce innate immune responses, making them more versatile and potentially more effective across multiple indications.
Pursuing Quality While Maintaining Process Control With Richard Moroney, Ph.D.
Q: What are the common levers for control in bioprocessing that cause the most issues?
The molecule being produced and the host organism are the main sources of variation; scale-up challenges in biology complicate maintaining uniform conditions, with downstream processing and contamination control often being critical leverage points.
Pursuing Quality While Maintaining Process Control With Richard Moroney, Ph.D.
Q: What would your advice be to folks how they can reframe their thinking about quality and process control?
Don't stop asking the hard questions and maintain vigilance against unconscious competence by continuously measuring where you are, defining where you want to go, and figuring out how to get there through improved process controls.

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Frequently Asked Questions About Better Biopharma

What is Better Biopharma about and what kind of topics does it cover?

Centered around the theme of improvement in biopharmaceuticals, content focuses on advancements in manufacturing practices, regulatory challenges, and innovative therapies within the life sciences sector. Each episode features conversations with leading experts who share insights on their strategies, research, and the latest trends impacting drug development and biomanufacturing. The discussions cover a wide array of topics such as gene therapy, vaccine development, regenerative medicine, and AI applications in operations research. This podcast aims to educate and inspire professionals engaged in biopharma, fostering collaboration and innovative thinking to enhance patient outcomes and industry standards.

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Which podcasts are similar to Better Biopharma?

These podcasts share a similar audience with Better Biopharma:

1. BioSpace

How many episodes of Better Biopharma are there?

Better Biopharma launched 8 months ago and published 19 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on Better Biopharma?

Recent guests on Better Biopharma include:

1. Richard Moroney
2. Pete O'Heeron
3. Hamid Khoja
4. Eric Doerr
5. Dr. Tugce Martagan
6. Dr. Tinglong Dai
7. Sean Tucker
8. Patrick Bilbo

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