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Better Biopharma

Tyler Menichiello
Biopharmaceuticals
Biomanufacturing
CAR T Therapy
Alzheimer's Disease
Clinical Trials
Drug Development
FDA
Process Development
Therapies
Antibody Drug Development
Biotechnology
C Difficile Infection
Lumen Biosciences
G Protein-Coupled Receptors
Functional Antibody Screening
Johnson & Johnson
Neuroinflammation
Conditionally Active Biologics
Oral Vaccines
Artificial Intelligence

“How can biopharma improve?” This question is the guiding ethos of the Better Biopharma podcast. Through conversations with experts across the biopharma landscape, host Tyler Menichiello explores the work being done to make better medicines and optimize manufacturing. Each episode is a dive into the guest's methods, their curiosity, and their determination. By shining a light on the visionaries pu... more

PublishesTwice monthlyEpisodes23Founded10 months ago
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Life SciencesScience

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Artwork for Better Biopharma

Latest Episodes

In Part 2 of this conversation on “Better Biopharma,” panelists from the Bioprocess Online Live event “Optimizing Process Development Through Upstream And Downstream Integration” continue their discussion about how upstream and downstream development... more

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In this episode of “Better Biopharma,” panelists from the Bioprocess Online Live event “Optimizing Process Development Through Upstream And Downstream Integration” continue their conversation about how upstream and downstream development teams can wo... more

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In this episode of “Better Biopharma,” host Tyler Menichiello speaks with Michael McCullar, Ph.D., CEO at RegCell, a cell-therapy company developing regulatory T cell (Treg) therapies for autoimmune diseases. They discuss RegCell’s origins and its di... more

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In this episode of “Better Biopharma,” host Tyler Menichiello is joined by Nikolai Sopko, MD, Ph.D., chief operating officer, chief scientific officer, and director at PolarityBio, a biotech company developing SkinTE, an investigational autologous re... more

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Recent Guests

Eric Dewar
Technical lead for drug substance manufacturing science and technology at Sanofi
Sanofi
Episode: Aligning Upstream And Downstream Development (Part 1)
Mark Fitchman
Founder, president, and CEO of Somatech
Somatech
Episode: Aligning Upstream And Downstream Development (Part 1)
Doug McDonald
Director of purification process development at ImmunoGen
ImmunoGen
Episode: Aligning Upstream And Downstream Development (Part 1)
Brandon Salinas
VP of Process Sciences at Umoja Biopharma
Umoja Biopharma
Episode: Aligning Upstream And Downstream Development (Part 1)
Michael McCullar
CEO of RegCell
RegCell
Episode: Reprogramming T Cells And Reducing Manufacturing Costs With RegCell’s Michael McCullar, Ph.D.
Nikolai Sopko
Chief Operating Officer, Chief Scientific Officer, and Director at PolarityBio
PolarityBio
Episode: Scaling Regenerative Medicine Production With PolarityBio’s Nikolai Sopko, MD, Ph.D.
Richard Moroney
Managing Director at Stat Consulting
Stat Consulting
Episode: Pursuing Quality While Maintaining Process Control With Richard Moroney, Ph.D.
Pete O'Heeron
CEO of FibroBiologics
FibroBiologics
Episode: Unlocking The Therapeutic Power Of Fibroblasts With Pete O’Heeron And Hamid Khoja, Ph.D.
Hamid Khoja
Chief Scientific Officer of FibroBiologics
FibroBiologics
Episode: Unlocking The Therapeutic Power Of Fibroblasts With Pete O’Heeron And Hamid Khoja, Ph.D.

Host

Tyler Menichiello
Host of Better Biopharma

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Talking Points

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Reprogramming T Cells And Reducing Manufacturing Costs With RegCell’s Michael McCullar, Ph.D.
Q: Where do you see point-of-care manufacturing fitting in, and how is RegCell contributing?
Point-of-care production is envisioned through automated, closed systems that can operate in smaller centers, reducing the need for large GMP facilities and improving patient access; analytics and in situ monitoring will further streamline the process.
Reprogramming T Cells And Reducing Manufacturing Costs With RegCell’s Michael McCullar, Ph.D.
Q: What are the hurdles to improving commercial viability, particularly manufacturing cost?
Automation and the exclusion of viral vectors, combined with a lighter materials bill of materials and reduced idle capacity, are central to lowering costs; the aim is to push production closer to patients through scalable, closed systems to reduce labor and facility expenses.
Unlocking The Therapeutic Power Of Fibroblasts With Pete O’Heeron And Hamid Khoja, Ph.D.
Q: What is the regulatory outlook for spheroid-based therapies in the US compared to Australia?
Australia has shown receptivity to the technology in early trials; in the US, the plan is to work closely with the FDA to build INDs, leveraging the evolving regulatory landscape that is adapting to cell-based therapies and regimens beyond traditional small molecules.
Unlocking The Therapeutic Power Of Fibroblasts With Pete O’Heeron And Hamid Khoja, Ph.D.
Q: What are the manufacturing challenges for fibroblast spheroids and how are you addressing them?
The team had to invent bespoke in-house infrastructure, including specialized trays, scalable culture systems, and custom assays to measure identity, potency, and viability in a 3D spheroid format, along with transferring the process to contract manufacturers with careful tech transfer and regulatory alignment.
Unlocking The Therapeutic Power Of Fibroblasts With Pete O’Heeron And Hamid Khoja, Ph.D.
Q: Why have fibroblasts, particularly fibroblasts in spheroid form, emerged as a compelling therapeutic modality?
Fibroblasts are abundant, easier to harvest and scale, and less prone to spontaneous differentiation than stem cells. Spheroids further enhance their immune modulation, prolong target exposure, and reduce innate immune responses, making them more versatile and potentially more effective across multiple indications.

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Frequently Asked Questions About Better Biopharma

What is Better Biopharma about and what kind of topics does it cover?

Biopharma manufacturing, regulatory strategy, and cutting-edge therapies are recurring through-lines across recent episodes. Conversations frequently center on aligning upstream and downstream development, improving data interoperability, and building scalable, compliant manufacturing processes for advanced therapies—ranging from cell therapies and regenerative medicine to novel vaccine platforms. Guests bring practitioner perspectives on cost reduction, automation, workforce development, AI and operations research in biomanufacturing, and regulatory navigation for new modalities. A standout pattern is the emphasis on practical, real-world constraints and leadership approaches that bridge science, manufacturing, and quality to accelerate cl... more

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1. The Readout Loud
2. All-In with Chamath, Jason, Sacks & Friedberg

How many episodes of Better Biopharma are there?

Better Biopharma launched 10 months ago and published 23 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on Better Biopharma?

Recent guests on Better Biopharma include:

1. Eric Dewar
2. Mark Fitchman
3. Doug McDonald
4. Brandon Salinas
5. Michael McCullar
6. Nikolai Sopko
7. Richard Moroney
8. Pete O'Heeron

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