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Artwork for ASTCT Talks

ASTCT Talks

ASTCT
Chronic GVHD
CAR T-Cell Therapy
Graft-Versus-Host Disease
Multiple Myeloma
Cord Blood Transplantation
Omaduba Cell
Gene Therapy
Car-T Therapy
Melanoma
CAR T Cell Therapy
Duke Cancer Institute
CAR T Therapy
Tumor Infiltrating Lymphocytes
CD19 Car-T
Immune Effector Cell Associated Enterocolitis
Tumor-Infiltrating Lymphocytes
T-Cell Lymphoma
Infections In GVHD
Steroids
Fatigue

ASTCT Talks is the official podcast of the American Society for Transplantation and Cellular Therapy (ASTCT). We chat with industry leaders from all areas of the blood and marrow transplantation and cellular therapy field, including doctors, physician assistants, pharmacists, nurses, administrators, social workers, and more. We hope you enjoy listening!

PublishesWeeklyEpisodes82Founded6 years ago
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MedicineHealth & Fitness

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Artwork for ASTCT Talks

Latest Episodes

In this episode of ASTCT Talks, host Terri Lynn Shigle, PharmD, BCOP, clinical pharmacy specialist with Stem Cell Transplantation and Cellular Therapy Department at The University of Texas MD Anderson Cancer Center and current ASTCT director of pharm... more

In a cobranded episode between Oncology On the Go, hosted by CancerNetwork®, and the American Society for Transplantation and Cellular Therapy’s (ASTCT) program ASTCT Talks, Terri Lynn Shigle, PharmD, BCOP hosted Vinita Pai, PharmD, MS, BCPPS, who sp... more

In this episode of ASTCT Talks, Dr. Nirali Shah welcomes Crystal Mackall, MD, the Ernest and Amelia Gallo Family Professor at Stanford University and a pioneer in immuno-oncology and cellular therapy, for a conversation in the Titans of Transplant se... more

In this episode of ASTCT Talks, host Terri Lynn Shigle, PharmD, BCOP, Clinical Pharmacy Specialist in the Stem Cell Transplantation and Cellular Therapy Department at The University of Texas MD Anderson Cancer Center, sits down with Lauren Campasano,... more

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Recent Guests

Dr. Mark Hamilton
Assistant professor in the Department of Lymphoma and Myeloma at MD Anderson
MD Anderson Cancer Center
Episode: Understanding Immune Effector Cell-Associated Enterocolitis After CAR T-Cell Therapy
Vinita Pai
Faculty at the College of Pharmacy, Ohio State University, with extensive pediatric transplant experience
The Ohio State University College of Pharmacy
Episode: Exploring CAR T Updates in Pediatric Acute Lymphoblastic Leukemia
Crystal Mackall
Ernest and Amelia Gallo Family Professor and Professor of Pediatrics and Medicine at Stanford University
Stanford University
Episode: Titans of Transplant Featuring Dr. Crystal Mackall
Lauren Campasano
Oncology social worker
Robert Wood Johnson Barnabas Health, Melchiori Cancer Center, Livingston, New Jersey
Episode: The Role of the Social Worker in CAR T Care
Stephanie Goff
Surgical oncologist and cellular therapist
National Cancer Institute (NIH) backdrop; discussed experience at NCI
Episode: TIL Therapy for Solid Tumors
Allison Betof
Physician scientist focusing on tumor microenvironment and cell therapy
Stanford; melanoma program lead
Episode: TIL Therapy for Solid Tumors
Cath Bollard
Senior Vice President and Chief Research Officer at Children's National Hospital; Distinguished Professor and leader in cancer immunotherapy and transplantation biology
Children's National Hospital; George Washington University; GW Cancer Center
Episode: Titans of Transplant: Catherine Bollard, MBChB, MD
Mitchell Horwitz
Dr. Mitchell Horwitz from Duke Cancer Institute
Duke Cancer Institute
Episode: Navigating the Dynamic Landscape of Stem Cell Transplantation
Ben Watkins
Division chief of pediatric hematology and oncology and director of stem cell transplant at Tulane University and Manning Family Children's Hospital
Tulane University and Manning Family Children's Hospital
Episode: GVHD in Pediatrics: Acute and Chronic Risk

Hosts

Terri Lynn Shigle
Host of ASTCT Talks
Nirali Shah
Host of ASTCT Talks podcast
Corey Cutler
Host of ASTCT Talks

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Talking Points

Recent interactions between the hosts and their guests.

Understanding Immune Effector Cell-Associated Enterocolitis After CAR T-Cell Therapy
Q: What is the current approach to treatment for IEC-EC and when are steroids used?
The standard approach emphasizes T-cell-directed therapies and supportive care rather than starting with systemic steroids; many patients receive mesalamine, budesonide, and IVIG as needed, with cyclophosphamide or cyclosporine as effective second-line options, while systemic steroids are generally not used first-line.
Understanding Immune Effector Cell-Associated Enterocolitis After CAR T-Cell Therapy
Q: Can you describe the IEC-EC presentation and how it differs from other causes of diarrhea after CAR-T therapy?
IEC-EC typically presents with severe, large-volume diarrhea months after CAR-T therapy, with high clinical burden and gut involvement—primarily in the duodenum—where CAR T cells are seen infiltrating the tissue; infections are common differential diagnoses, and endoscopic/pathologic confirmation with CAR T-cell detection guides diagnosis.
Titans of Transplant Featuring Dr. Crystal Mackall
Q: So with that Crystal, can you begin by sharing how you ended up in medicine? And then beyond that, what made you go into cell therapy and transplant?
Crystal explains a lifelong drive toward medicine rooted in personal experiences with cancer, followed by a pivotal interest in immunotherapy sparked by early literature, particularly Steve Rosenberg's work on interleukin-2 and immune cell therapies, which redirected her toward physician-scientist training and research.
Titans of Transplant: Catherine Bollard, MBChB, MD
Q: What do you see as the biggest gaps or opportunities in pediatric cell therapy today?
There is a critical need to translate academic advances into industry-ready products for pediatric patients, particularly for lymphomas and solid tumors, and to create models that push therapies from phase trials to pivotal trials and commercialization.
Titans of Transplant: Catherine Bollard, MBChB, MD
Q: Could you tell us about how you came to this career path and why you chose medicine?
Her journey started in high school after a friend's battle with EBV-positive Hodgkin lymphoma, which catalyzed her focus on pediatric hematology and immunotherapies to target cancer cells while sparing healthy tissue.

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Frequently Asked Questions About ASTCT Talks

What is ASTCT Talks about and what kind of topics does it cover?

The conversations center on cell therapy, transplantation, and immunotherapy, with a steady emphasis on real-world clinical practice, program implementation, and multidisciplinary care. Episodes frequently explore CAR-T toxicity management, GVHD prevention, infection prophylaxis, and the evolving regulatory and logistical landscape that surrounds cutting-edge therapies. Notable threads include pediatric and adult perspectives on graft-versus-host disease, social and psychosocial aspects of care, and the operational realities of building cellular therapy programs (from manufacturing to patient access). A distinguishing trait is the blend of clinician-scientist guests, program leaders, and pharmacology/clinical pharmacy voices, which helps tr... more

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Which podcasts are similar to ASTCT Talks?

These podcasts share a similar audience with ASTCT Talks:

1. Blood Podcast
2. Hematologic Oncology Update
3. Core IM | Internal Medicine Podcast
4. Planet Money
5. NEJM This Week

How many episodes of ASTCT Talks are there?

ASTCT Talks launched 6 years ago and published 82 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on ASTCT Talks?

Recent guests on ASTCT Talks include:

1. Dr. Mark Hamilton
2. Vinita Pai
3. Crystal Mackall
4. Lauren Campasano
5. Stephanie Goff
6. Allison Betof
7. Cath Bollard
8. Mitchell Horwitz

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