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Artwork for ASTCT Talks

ASTCT Talks

ASTCT
Chronic GVHD
Cord Blood Transplantation
Graft-Versus-Host Disease
Omaduba Cell
Gene Therapy
Car-T Therapy
CAR T Cell Therapy
Multiple Myeloma
CAR T-Cell Therapy
Duke Cancer Institute
Tumor-Infiltrating Lymphocytes
Infections In GVHD
Steroids
T-Cell Lymphoma
Lifilucel
Hematopoietic Stem Cell Transplantation
Lymphoma
Vaccination In GVHD
Bispecific Antibodies
Ruxolitinib

ASTCT Talks is the official podcast of the American Society for Transplantation and Cellular Therapy (ASTCT). We chat with industry leaders from all areas of the blood and marrow transplantation and cellular therapy field, including doctors, physician assistants, pharmacists, nurses, administrators, social workers, and more. We hope you enjoy listening!

PublishesWeeklyEpisodes79Founded6 years ago
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Health & FitnessMedicine

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Artwork for ASTCT Talks

Latest Episodes

In this episode of ASTCT Talks, host Terri Lynn Shigle, PharmD, BCOP, Clinical Pharmacy Specialist in the Stem Cell Transplantation and Cellular Therapy Department at The University of Texas MD Anderson Cancer Center, sits down with Lauren Campasano,... more

In this episode of ASTCT Talks, host Daniel Olson, MD, of the University of Chicago, is joined by Stephanie Goff, MD, of the National Cancer Institute (NCI), and Allison Betof, MD, PhD, of Stanford Medicine to discuss the evolution and expanding role... more

In this episode of ASTCT Talks, Dr. Nirali Shah talks with Dr. Cath Bollard as part of the Titans of Transplant series to explore her remarkable career journey and lasting impact on the field of transplantation and cellular therapy. From early inspir... more

In a cobranded episode between Oncology on the Go, hosted by CancerNetwork®, and the American Society for Transplantation and Cellular Therapy (ASTCT)’s program ASTCT Talks, Mitchell E. Horwitz, MD, highlighted key developments and ongoing initiative... more

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Recent Guests

Mitchell Horwitz
Dr. Mitchell Horwitz from Duke Cancer Institute
Duke Cancer Institute
Episode: Navigating the Dynamic Landscape of Stem Cell Transplantation
Ben Watkins
Division chief of pediatric hematology and oncology and director of stem cell transplant at Tulane University and Manning Family Children's Hospital
Tulane University and Manning Family Children's Hospital
Episode: GVHD in Pediatrics: Acute and Chronic Risk
Pooja Khandelwal
Professor of pediatrics, division of bone marrow transplant and immune deficiency
Cincinnati Children's Hospital
Episode: GVHD in Pediatrics: Acute and Chronic Risk
Ken Cooke
Director of the pediatric blood and marrow transplantation program
Johns Hopkins Sidney Kimmel Comprehensive Cancer Center
Episode: GVHD in Pediatrics: Acute and Chronic Risk
Hitomi Hosoya
Physician scientist, hematologist focused on cellular therapy and CAR T-cell therapy
Cedars-Sinai Medical Center, Los Angeles; Stanford University (former)
Episode: Exploring and Managing Gastrointestinal-Related CAR T-Cell Lymphomas
Christy Duncan
Pediatric stem cell transplant physician focused on gene therapy
Pediatric stem cell transplant team
Episode: ASTCT Talks: Gene Therapy Today and Tomorrow
Sung-Yun Pai
Pediatric stem cell transplant physician scientist, NIH intramural program
NIH
Episode: ASTCT Talks: Gene Therapy Today and Tomorrow
Nosha Farhadfar
Medical Director of Research at Sarah Cannon Transplant and Cellular Therapy Program
Methodist San Antonio; Sarah Cannon Transplant and Cellular Therapy Program
Episode: Treatment Options for cGVHD: Adult vs. Pediatric Perspectives
Poojah Khandelwal
Associate Professor in the Division of Bone Marrow Transplantation
Cincinnati Children's Hospital Medical Center
Episode: Treatment Options for cGVHD: Adult vs. Pediatric Perspectives

Hosts

Corey Cutler
Host of ASTCT Talks; affiliated with Dana-Farber Cancer Institute and Harvard Medical School
Marc Braunstein
Host of the episode; co-host providing clinical commentary

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Talking Points

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Cord Blood Transplantation: Past, Present and Future Innovations
Q: What new approaches and technologies look most promising for expanding cord blood's role in transplantation?
Milano outlines multiple strategies: using single versus double cord units based on cell dose and HLA mismatches, exploring expansion technologies to speed engraftment, and developing “upload cord” and mixed-unit approaches that could improve leukemia control while maintaining manageable relapse and GVHD risks.
Optimizing Care for TILs, Cellular Therapy in Melanoma and Solid Tumors
Q: Natalie, in your experience, how do you decide whether to deliver all six IL-2 doses or to delay/discontinue based on toxicity?
There isn't a strict correlation between the number of IL-2 doses and response; decision-making is patient-specific, prioritizing safety with predefined stop/go criteria, close monitoring of organ function, and mobilizing supportive care to manage toxicities while preserving potential benefit.
Optimizing Care for TILs, Cellular Therapy in Melanoma and Solid Tumors
Q: Bryant, how does Lifilucel's efficacy in this setting compare to prior therapies for metastatic melanoma after checkpoint inhibitors and BRAF/MEK inhibitors?
Earlier data showed Lifilucel achieved an overall response rate around 31.4% with a subset achieving complete responses, and durability appeared favorable with a four-year survival around 47%, marking a meaningful improvement over historical options that had limited efficacy after prior therapies.
ASTCT Talks: Gene Therapy Today and Tomorrow
Q: What infrastructure should a center build before attempting to deliver gene therapies commercially?
Focus on building a robust process rather than the product, map out every step of the patient and center journey, secure payer engagement and insurance authorization, train multidisciplinary teams, and establish strong communication networks across transplant, pharmacology, and administration to support scalable delivery.
ASTCT Talks: Gene Therapy Today and Tomorrow
Q: What are the biggest barriers to implementing gene therapy at scale, given current developments?
Barriers include access and equity, the complexity of implementing trials in diverse centers, long-term safety and follow-up, payer and reimbursement challenges, and the need for centralized, well-coordinated teams to manage the patient and center journey.

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Frequently Asked Questions About ASTCT Talks

What is ASTCT Talks about and what kind of topics does it cover?

This program spotlights cutting-edge developments in hematopoietic cell transplantation and cellular therapy, often centering on real-world clinical decision-making, trial results, and emerging therapies. Recent episodes tackle cord blood transplantation, GVHD prevention and management in both pediatric and adult patients, CAR T-cell therapies and sequencing with BCMA-targeted agents, gene therapies, immune reconstitution, infection prevention, and survivorship issues such as cognitive health and pulmonary complications post-transplant. A notable strength is the breadth of expert voices—from transplant physicians and infectious disease specialists to pharmacologists and researchers at leading centers—providing practical guidance, treatment ... more

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Which podcasts are similar to ASTCT Talks?

These podcasts share a similar audience with ASTCT Talks:

1. Two Onc Docs
2. WolverHeme Happy Hour
3. Blood Cancer Talks
4. Wait Wait... Don't Tell Me!
5. Science Friday

How many episodes of ASTCT Talks are there?

ASTCT Talks launched 6 years ago and published 79 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on ASTCT Talks?

Recent guests on ASTCT Talks include:

1. Mitchell Horwitz
2. Ben Watkins
3. Pooja Khandelwal
4. Ken Cooke
5. Hitomi Hosoya
6. Christy Duncan
7. Sung-Yun Pai
8. Nosha Farhadfar

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